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Anti-EED Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Polycomb protein EED is a protein that in humans is encoded by the EED gene. It is a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein interacts with enhancer of zeste 2, the cytoplasmic tail of integrin β7, immunodeficiency virus type 1 (HIV-1) MA protein, and histone deacetylase proteins. Furthermore, this protein mediates repression of gene activity through histone deacetylation, and may act as a specific regulator of integrin function. Two transcript variants encoding distinct isoforms have been identified for this gene.

Synonyms

Polycomb protein EED; hEED; WD protein associating with integrin cytoplasmic tails 1; WAIT-1; EED

Gene Name

EED

Gene ID

8726

UniProt

O75530

Host

Rabbit

Reactivity

Human, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human EED recombinant protein (Position: M256-R441) . Human EED shares 100% amino acid (aa) sequence identity with mouse EED.

Clonality

Polyclonal

Tissue Specificity

Expressed in brain, colon, heart, kidney, liver, lung, muscle, ovary, peripheral blood leukocytes, pancreas, placenta, prostate, spleen, small intestine, testis, thymus and uterus. Appears to be overexpressed in breast and colon cancer. .

Applications

Flow Cytometry

Field of Research

Chromatin Modifying Enzymes, Chromatin Remodeling, Epigenetics and Nuclear Signaling, Methylation

Purification

Immunogen affinity purified.

Form

Liquid

Function

Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. .

References & Citations

1. Entrez Gene: EED embryonic ectoderm development. 2. Rietzler M, Bittner M, Kolanus W, Schuster A, Holzmann B (Nov 1998) . The human WD repeat protein WAIT-1 specifically interacts with the cytoplasmic tails of beta7-integrins. J. Biol. Chem. 273 (42) : 27459–66. 3. Schumacher A, Lichtarge O, Schwartz S, Magnuson T (Jan 1999) . The murine Polycomb-group gene eed and its human orthologue: functional implications of evolutionary conservation. Genomics 54 (1) : 79–88.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

50198 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Polycomb protein EED

Subcellular Location

Nucleus. Chromosome. Transiently colocalizes with XIST at inactive X chromosomes.

Sequence Similarities

Belongs to the WD repeat ESC family.

Protein Name

Polycomb protein EED

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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