Anti-Cdc37 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Hsp90 co-chaperone Cdc37, also called P50CDC37, is a protein that in humans is encoded by the CDC37 gene. The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This gene is mapped to 19p13.2. And this protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in ing Hsp90 to its target kinases.
Synonyms
Hsp90 co-chaperone Cdc37; Hsp90 chaperone protein kinase-targeting subunit; p50Cdc37; Hsp90 co-chaperone Cdc37, N-terminally processed; CDC37; CDC37A
Gene Name
CDC37
Gene ID
11140
UniProt
Q16543
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
E.coli-derived human Cdc37 recombinant protein (Position: M216-V378) . Human Cdc37 shares 95.7% and 95.1% amino acid (aa) sequence identity with mouse and rat Cdc37, respectively.
Clonality
Polyclonal
Tissue Specificity
T-cell and macrophage specific.
Applications
Flow Cytometry
Field of Research
Cell Biology, Cell Cycle, Epigenetics and Nuclear Signaling, Kinases/Phosphatases
Purification
Immunogen affinity purified.
Form
Liquid
Function
Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. .
References & Citations
1. Chen, G., Cao, P., Goeddel, D. V. TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90. Molec. Cell 9: 401-410, 2002. 2. Vaughan, C. K., Mollapour, M., Smith, J. R., Truman, A., Hu, B., Good, V. M., Panaretou, B., Neckers, L., Clarke, P. A., Workman, P., Piper, P. W., Prodromou, C., Pearl, L. H.Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37. Molec. Cell 31: 886-895, 2008.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
44468 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Hsp90 co-chaperone Cdc37
Subcellular Location
Cytoplasm .
Sequence Similarities
Belongs to the CDC37 family.
Protein Name
Hsp90 co-chaperone Cdc37
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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