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Anti-AHSG Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Alpha-2-HS-glycoprotein (AHSG), also known as fetuin-A, is a protein that in humans is encoded by the AHSG gene. Fetuin-A belongs to the fetuin class of plasma binding proteins and is more abundant in fetal than adult blood. Its gene is mapped to 3q27. The protein is commonly present in the cortical plate of the immature cerebral cortex and bone marrow hemopoietic matrix. It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue.

Synonyms

Alpha-2-HS-glycoprotein; Alpha-2-Z-globulin; Ba-alpha-2-glycoprotein; Fetuin-A; Alpha-2-HS-glycoprotein chain A; Alpha-2-HS-glycoprotein chain B; AHSG; FETUA; PRO2743

Gene Name

AHSG

Gene ID

197

UniProt

P02765

Host

Rabbit

Reactivity

Human, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human Fetuin A, different from the related mouse and rat sequences by thirteen amino acids.

Clonality

Polyclonal

Tissue Specificity

Synthesized in liver and selectively concentrated in bone matrix. Secreted in plasma. It is also found in dentin in much higher quantities than other plasma proteins.

Applications

Flow Cytometry

Field of Research

Cardiovascular, Metabolism, Neurogenesis, Neurology Process, Neuroscience, Obesity, Serum Proteins

Purification

Immunogen affinity purified.

Form

Liquid

Function

Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions.

References & Citations

1. Entrez Gene: AHSG alpha-2-HS-glycoprotein. 2. Osawa M, Umetsu K, Sato M, Ohki T, Yukawa N, Suzuki T, Takeichi S (September 1997) . Structure of the gene encoding human alpha 2-HS glycoprotein (AHSG) . Gene 196 (1-2) : 121–5. 3. Rizzu P, Baldini A (1995) . Three members of the human cystatin gene superfamily, AHSG, HRG, and KNG, map within one megabase of genomic DNA at 3q27. Cytogenet. Cell Genet. 70 (1-2) : 26–8.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

39325 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Alpha-2-HS-glycoprotein

Subcellular Location

Secreted.

Sequence Similarities

Belongs to the fetuin family.

Protein Name

Alpha-2-HS-glycoprotein

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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