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Anti-MCSF/CSF1 Antibody Fluoro550 Conjugated

Product Specifications

Background

M-CSF (or CSF-1) is a hematopoietic growth factor that is involved in the proliferation, differentiation, and survival ofmonocytes, macrophages, and bone marrow progenitor cells. M-CSF affects macrophages and monocytes in several ways, including stimulating increased phagocytic and chemotactic activity, and increased tumour cell cytotoxicity. The role of M-CSF is not only restricted to the monocyte/macrophage cell lineage. By interacting with its membrane receptor (CSF1R or M-CSF-R encoded by the c-fms proto-oncogene), M-CSF also modulates the proliferation of earlier hematopoietic progenitors and influence numerous physiological processes involved in immunology, metabolism, fertility and pregnancy.

Synonyms

Macrophage colony-stimulating factor 1; CSF-1; MCSF; Processed macrophage colony-stimulating factor 1; Csf1; Csfm

Gene Name

Csf1

Gene ID

12977

UniProt

P07141

Host

Rabbit

Reactivity

Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E. coli-derived mouse MCSF recombinant protein (Position: K33-E262) . Mouse MCSF shares 80.9 % and 88.6% amino acid (aa) sequence identity with human and rat MCSF, respectively.

Clonality

Polyclonal

Tissue Specificity

Non-neural epithelial tissues.

Applications

Flow Cytometry

Field of Research

Atherosclerosis, Cardiovascular, Cytokines, Immunology, Innate Immunity, Macrophage/Inflammation, Vascular Inflammation

Purification

Immunogen affinity purified.

Form

Liquid

Function

Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.

References & Citations

1. Fixe P, Praloran V (June 1997) .Macrophage colony-stimulating-factor (M-CSF or CSF-1) and its receptor: structure-function relationships. Eur. Cytokine Netw. 8 (2) : 125–36. 2. Nemunaitis J (April 1993) . Macrophage function activating cytokines: potential clinical application. Crit. Rev. Oncol. Hematol. 14 (2) : 153–71. 3. Stanley ER, Berg KL, Einstein DB, Lee PS, Pixley FJ, Wang Y, Yeung YG (January 1997) . Biology and action of colony--stimulating factor-1. Mol. Reprod. Dev. 46 (1) : 4–10.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

60649 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Macrophage colony-stimulating factor 1

Subcellular Location

Cell membrane ; Single-pass type I membrane protein .

Sequence Similarities

Contains 5 cadherin domains.

Protein Name

Macrophage colony-stimulating factor 1

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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