What is the catalog number for Anti-MCSF/CSF1 Antibody Fluoro488 Conjugated?

The catalog number for Anti-MCSF/CSF1 Antibody Fluoro488 Conjugated is PB9562-Fluoro488.

What sizes are available for Anti-MCSF/CSF1 Antibody Fluoro488 Conjugated?

Anti-MCSF/CSF1 Antibody Fluoro488 Conjugated is available in the following size(s): 100 µg/Vial.

Is Anti-MCSF/CSF1 Antibody Fluoro488 Conjugated in stock?

Anti-MCSF/CSF1 Antibody Fluoro488 Conjugated is currently made to order / not held in immediate stock. Contact us for lead time.

Do you offer custom or private-label production of this type of product?

Yes, custom antibody development and private-label production services are available. Contact our sales team to discuss your target, timeline, and quantity requirements.

What is the immunogen used to generate this antibody?

Immunogen or antigen details used to raise this antibody are listed on the product datasheet under immunogen information.

What is the recommended positive control for this assay?

A recommended positive control, where one is specified by the manufacturer, is listed on the datasheet or in the assay protocol.

Anti-MCSF/CSF1 Antibody Fluoro488 Conjugated

Product Specifications

Background

M-CSF (or CSF-1) is a hematopoietic growth factor that is involved in the proliferation, differentiation, and survival ofmonocytes, macrophages, and bone marrow progenitor cells. M-CSF affects macrophages and monocytes in several ways, including stimulating increased phagocytic and chemotactic activity, and increased tumour cell cytotoxicity. The role of M-CSF is not only restricted to the monocyte/macrophage cell lineage. By interacting with its membrane receptor (CSF1R or M-CSF-R encoded by the c-fms proto-oncogene), M-CSF also modulates the proliferation of earlier hematopoietic progenitors and influence numerous physiological processes involved in immunology, metabolism, fertility and pregnancy.

Synonyms

Macrophage colony-stimulating factor 1; CSF-1; MCSF; Processed macrophage colony-stimulating factor 1; Csf1; Csfm

Gene Name

Csf1

Gene ID

12977

UniProt

P07141

Host

Rabbit

Reactivity

Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E. coli-derived mouse MCSF recombinant protein (Position: K33-E262) . Mouse MCSF shares 80.9 % and 88.6% amino acid (aa) sequence identity with human and rat MCSF, respectively.

Clonality

Polyclonal

Tissue Specificity

Non-neural epithelial tissues.

Applications

Flow Cytometry

Field of Research

Atherosclerosis, Cardiovascular, Cytokines, Immunology, Innate Immunity, Macrophage/Inflammation, Vascular Inflammation

Purification

Immunogen affinity purified.

Form

Liquid

Function

Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.

References & Citations

1. Fixe P, Praloran V (June 1997) .Macrophage colony-stimulating-factor (M-CSF or CSF-1) and its receptor: structure-function relationships. Eur. Cytokine Netw. 8 (2) : 125–36. 2. Nemunaitis J (April 1993) . Macrophage function activating cytokines: potential clinical application. Crit. Rev. Oncol. Hematol. 14 (2) : 153–71. 3. Stanley ER, Berg KL, Einstein DB, Lee PS, Pixley FJ, Wang Y, Yeung YG (January 1997) . Biology and action of colony--stimulating factor-1. Mol. Reprod. Dev. 46 (1) : 4–10.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

60649 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

Gene Name Synonym

Macrophage colony-stimulating factor 1

Subcellular Location

Cell membrane ; Single-pass type I membrane protein .

Sequence Similarities

Contains 5 cadherin domains.

Protein Name

Macrophage colony-stimulating factor 1

Isotype

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

BNC881035-100 1x 100 µL

CD8 (C8/1035), CF488A conjugate, 0.1mg/mL

View Details

BNC550645-100 1x 100 µL

FOXP3 (3G3), CF555 conjugate, 0.1mg/mL

View Details

BNC430151-100 1x 100 µL

CD11a (Cris-3), CF543 conjugate, 0.1mg/mL

View Details

BNC470304-500 1x 500 µL

CD106 / VCAM1 (B-K9), CF647 conjugate, 0.1mg/mL

View Details

BNC680437-500 1x 500 µL

CD47 (B6H12.2), CF568 conjugate, 0.1mg/mL

View Details

BNC040146-100 1x 100 µL

CD10 (CB-CALLA), CF405S conjugate, 0.1mg/mL

View Details

Anti-MCSF/CSF1 Antibody Fluoro488 Conjugated

Product Specifications

Background

Synonyms

Gene Name

Gene ID

UniProt

Host

Reactivity

Cross Reactivity

Immunogen

Clonality

Tissue Specificity

Applications

Field of Research

Purification

Form

Function

References & Citations

Storage Conditions

Calculated Molecular Weight

Specificity

Applications Notes

Gene Name Synonym

Subcellular Location

Sequence Similarities

Protein Name

Isotype

Contents

Frequently Asked Questions

Explore Other Products

CD8 (C8/1035), CF488A conjugate, 0.1mg/mL

FOXP3 (3G3), CF555 conjugate, 0.1mg/mL

CD11a (Cris-3), CF543 conjugate, 0.1mg/mL

CD106 / VCAM1 (B-K9), CF647 conjugate, 0.1mg/mL

CD47 (B6H12.2), CF568 conjugate, 0.1mg/mL

CD10 (CB-CALLA), CF405S conjugate, 0.1mg/mL