Anti-Endothelin B Receptor/EDNRB Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Endothelin receptor type B, also known as ETB is a protein that in humans is encoded by the EDNRB gene. The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Synonyms

Endothelin B receptor; ET-B; ET-BR; Endothelin receptor non-selective type; EDNRB; ETRB

Gene Name

EDNRB

Gene ID

1910

UniProt

P24530

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human EDNRB, different from the related mouse and rat sequences by one amino acid.

Clonality

Polyclonal

Tissue Specificity

Expressed in placental stem villi vessels, but not in cultured placental villi smooth muscle cells. .

Applications

Flow Cytometry

Field of Research

G Protein Signaling, Signal Transduction, Signaling Pathway

Purification

Immunogen affinity purified.

Form

Liquid

Function

Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. .

References & Citations

1. Entrez Gene: EDNRB endothelin receptor type B. 2. Cyr C, Huebner K, Druck T, Kris R (November 1991) . Cloning and chromosomal localization of a human endothelin ETA receptor. Biochem. Biophys. Res. Commun. 181 (1) : 184–90.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

49644 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

Gene Name Synonym

Endothelin B receptor

Subcellular Location

Cell membrane; Multi-pass membrane protein.

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily.

Protein Name

Endothelin B receptor

Isotype

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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Anti-Endothelin B Receptor/EDNRB Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Synonyms

Gene Name

Gene ID

UniProt

Host

Reactivity

Cross Reactivity

Immunogen

Clonality

Tissue Specificity

Applications

Field of Research

Purification

Form

Function

References & Citations

Storage Conditions

Calculated Molecular Weight

Specificity

Applications Notes

Gene Name Synonym

Subcellular Location

Sequence Similarities

Protein Name

Isotype

Contents

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