Anti-CCN1/CYR61 Antibody Picoband® Fluoro647 Conjugated

Cysteine-rich angiogenic inducer 61 (CYR61) or CCN family member 1 (CCN1), is a matricellular protein that in humans is encoded by the CYR61 gene. CYR61 is a secreted, extracellular matrix (ECM) -associated signaling protein of the CCN family (CCN intercellular signaling protein) . And it is capable of regulating a broad range of cellular activities, including cell adhesion, migration, proliferation, differentiation, apoptosis, and senescence through interaction with cell surface integrin receptors and heparan sulfate proteoglycans. During embryonic development, CYR61 is critical for cardiac septal morphogenesis, blood vessel formation in placenta, and vascular integrity. In adulthood CYR61 plays important roles in inflammation and tissue repair, and is associated with diseases related to chronic inflammation, including rheumatoid arthritis, atherosclerosis, diabetes-related nephropathy and retinopathy, and many different forms of cancers.

Protein CYR61; CCN family member 1; Cysteine-rich angiogenic inducer 61; Insulin-like growth factor-binding protein 10; IBP-10; IGF-binding protein 10; IGFBP-10; Protein GIG1; CYR61; CCN1, GIG1, IGFBP10

E.coli-derived human CCN1 recombinant protein (Position: K54-D381) . Human CCN1 shares 91.8% and 92.1% amino acid (aa) sequence identity with mouse and rat CCN1, respectively.

Angiogenesis, Cancer, Cardiovascular, Extracellular Matrix, Growth Factors, Growth Factors/Hormones, Immunology, Integrins, Mesenchymal Stem Cells, Secreted Molecules, Signal Transduction, Stem Cells

Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. .

1. Lau LF (October 2011) . CCN1/CYR61: the very model of a modern matricellular protein. Cell. Mol. Life Sci. 68 (19) : 3149–63. 2. Jay P, Berge-Lefranc JL, Marsollier C, Mejean C, Taviaux S, Berta P (May 1997) . The human growth factor-inducible immediate early gene, CYR61, maps to chromosome 1p. Oncogene 14 (14) : 1753–7. 3. Jun JI, Lau LF (December 2011) . Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets. Nature Reviews Drug Discovery 10 (12) : 945–63.