Anti-CYP27B1 Antibody Picoband® Fluoro647 Conjugated

CYP27B1 belongs to the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the inner mitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3 at the 1alpha position. This reaction synthesizes 1alpha,25-dihydroxyvitamin D3, the active form of vitamin D3, which binds to the vitamin D receptor and regulates calcium metabolism. Thus this enzyme regulates the level of biologically active vitamin D and plays an important role in calcium homeostasis. Mutations in this gene can result in vitamin D-dependent rickets type I.

25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial;1.14.13.13;25-OHD-1 alpha-hydroxylase;25-hydroxyvitamin D (3) 1-alpha-hydroxylase; VD3 1A hydroxylase; Calcidiol 1-monooxygenase; Cytochrome P450 subfamily XXVIIB polypeptide 1; Cytochrome P450C1 alpha; Cytochrome P450VD1-alpha; Cytochrome p450 27B1; CYP27B1; CYP1ALPHA, CYP27B

A synthetic peptide corresponding to a sequence at the C-terminus of human CYP27B1, different from the related mouse and rat sequences by six amino acids.

Cancer, Cancer Metabolism, Cardiovascular, Cofactors, Vitamins/Minerals, Cytochromes, Endocrine Metabolism, Hormone Biosynthesis, Lipases, Lipid and Lipoprotein Metabolism, Lipid Metabolism, Lipids/Lipoproteins, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Mitochondrial, Mitochondrial Markers, Mitochondrial Metabolism, Pathways and Processes, Signal Transduction, Vitamins/Minerals

Catalyzes the conversion of 25-hydroxyvitamin D3 (25 (OH) D) to 1-alpha,25-dihydroxyvitamin D3 (1,25 (OH) 2D) plays an important role in normal bone growth, calcium metabolism, and tissue differentiation.

1. Entrez Gene: cytochrome P450. 2. Monkawa T, Yoshida T, Wakino S, Shinki T, Anazawa H, Deluca HF et al. (Oct 1997) . Molecular cloning of cDNA and genomic DNA for human 25-hydroxyvitamin D3 1 alpha-hydroxylase. Biochemical and Biophysical Research Communications 239 (2) : 527–33. 3. Takeyama K, Kitanaka S, Sato T, Kobori M, Yanagisawa J, Kato S (Sep 1997) . 25-Hydroxyvitamin D3 1alpha-hydroxylase and vitamin D synthesis. Science (New York, N.Y.) 277 (5333) : 1827–30.