Anti-CYP24A1 Antibody Picoband®

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. And this mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain. In regulating the level of vitamin D3, this enzyme plays a role in calcium homeostasis and the vitamin D endocrine system. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

1,25-dihydroxyvitamin D (3) 24-hydroxylase, mitochondrial;24-OHase; Vitamin D (3) 24-hydroxylase;1.14.13.126; Cytochrome P450 24A1; Cytochrome P450-CC24; CYP24A1; CYP24

E.coli-derived human CYP24A1 recombinant protein (Position: E153-R514) . Human CYP24A1 shares 86.2% amino acid (aa) sequence identity with both mouse and rat CYP24A1.

Cancer, Cancer Metabolism, Cardiovascular, Cofactors, Vitamins/Minerals, Cytochromes, Endocrine Metabolism, Hormone Biosynthesis, Lipases, Lipid and Lipoprotein Metabolism, Lipid Metabolism, Lipids/Lipoproteins, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Mitochondrial, Mitochondrial Markers, Mitochondrial Metabolism, Pathways and Processes, Signal Transduction, Vitamins/Minerals

Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25- hydroxyvitamin D (3) ) and calcitriol (1-alpha,25-dihydroxyvitamin D (3) ) . The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23- hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D (3) -26,23-lactone as end product.

1. Entrez Gene: CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1. 2. Dauber A, Nguyen TT, Sochett E, Cole DE, Horst R, Abrams SA, Carpenter TO, Hirschhorn JN (February 2012) . Genetic defect in CYP24A1, the vitamin D 24-hydroxylase gene, in a patient with severe infantile hypercalcemia. J. Clin. Endocrinol. Metab. 97 (2) : E268–74. 3. Sakaki T, Kagawa N, Yamamoto K, Inouye K (January 2005) . Metabolism of vitamin D3 by cytochromes P450. Front. Biosci. 10: 119–34.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.