Anti-CTGF Antibody Picoband® Fluoro647 Conjugated

CTGF, also known as CCN2 or connective tissue growth factor, is a matricellular protein of the CCN family of extracellular matrix-associated heparin-binding proteins (see also CCN intercellular signaling protein) . CTGF has important roles in many biological processes, including cell adhesion, migration, proliferation, angiogenesis, skeletal development, and tissue wound repair, and is critically involved in fibrotic disease and several forms of cancers. The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. And the encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis.

Connective tissue growth factor; CCN family member 2; Hypertrophic chondrocyte-specific protein 24; Insulin-like growth factor-binding protein 8; IBP-8; IGF-binding protein 8; IGFBP-8; CTGF; CCN2, HCS24, IGFBP8

E.coli-derived human CTGF recombinant protein (Position: R58-A349) . Human CTGF shares 95.5% and 95.9% amino acid (aa) sequence identity with mouse and rat CTGF, respectively.

Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. .

1. Chen CC, Lau LF (April 2009) . Functions and mechanisms of action of CCN matricellular proteins. Int. J. Biochem. Cell Biol. 41 (4) : 771–83. 2. Hall-Glenn F, Lyons KM (October 2011) . Roles for CCN2 in normal physiological processes. Cell. Mol. Life Sci. 68 (19) : 3209–17. 3. Jun JI, Lau LF (December 2011) . Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets. Nat Rev Drug Discov 10 (12) : 945–63.