Anti-Carbonic Anhydrase I/CA1 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Carbonic anhydrase 1 is an enzyme that in humans is encoded by the CA1 gene. It is a member of the Carbonic anhydrase. The CA1 gene is mapped to 8q22. CAI has got about 260 amino acids. This protein is highly expressed in erythrocytes. As catalysts of the reversible hydration of carbon dioxide, CAI participates in a variety of biologic processes like respiration, calcification, acid-base balance etc.
Synonyms
Carbonic anhydrase 1;4.2.1.1; Carbonate dehydratase I; Carbonic anhydrase B; CAB; Carbonic anhydrase I; CA-I; CA1
Gene Name
CA1
Gene ID
759
UniProt
P00915
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
E.coli-derived human CA1 recombinant protein (Position: D9-F261) . Human CA1 shares 78.5% and 81% amino acid (aa) sequence identity with mouse and rat CA1, respectively.
Clonality
Polyclonal
Tissue Specificity
Highly expressed in fetal lung, and kidney. In the adult, expression is mainly seen in lymphoid tissues, including spleen, thymus and peripheral blood lymphocytes.
Applications
Flow Cytometry
Field of Research
Angiogenesis, Cancer, Cell Adhesion, Cell Adhesion Proteins, Cytoskeleton/ECM, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Membrane Proteins, Neuroscience, Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea. .
References & Citations
1. Lowe N, Edwards YH, Edwards M, Butterworth PH (Nov 1991) . Physical mapping of the human carbonic anhydrase gene cluster on chromosome 8. Genomics 10 (4) : 882–8. 2. Entrez Gene: CA1 carbonic anhydrase I.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
28870 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Carbonic anhydrase 1
Subcellular Location
Cytoplasm.
Sequence Similarities
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Protein Name
Carbonic anhydrase 1
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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