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Anti-Butyrylcholinesterase/BCHE Antibody Picoband® Fluoro488 Conjugated

Selected Variant

PB9526-Fluoro488

Size: 100 µg/Vial

Product Specifications

Background

Butyrylcholinesterase (BCHE, or BuChE), also known as pseudocholinesterase or plasma cholinesterase, is a non-specific cholinesterase enzyme that hydrolyses many different choline esters. In humans, it is found primarily in the liver and is encoded by the BCHE gene. Mutant alleles at the BCHE locus are responsible for suxamethonium sensitivity. Homozygous persons sustain prolonged apnea after administration of the muscle relaxant suxamethonium in connection with surgical anesthesia. The activity of pseudocholinesterase in the serum is low and its substrate behavior is atypical. In the absence of the relaxant, the homozygote is at no known disadvantage.

Synonyms

Cholinesterase;3.1.1.8; Acylcholine acylhydrolase; Butyrylcholine esterase; Choline esterase II; Pseudocholinesterase; Bche

Gene Name

Bche

Gene ID

12038

UniProt

Q03311

Host

Rabbit

Reactivity

Mouse

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived mouse BCHE recombinant protein (Position: K263-E571) . Mouse BCHE shares 78% amino acid (aa) sequence identity with human BCHE.

Clonality

Polyclonal

Tissue Specificity

Present in most cells except erythrocytes.

Applications

Flow Cytometry

Field of Research

Alzheimer's Disease, Drug Metabolism, Metabolic Signaling Pathways, Metabolism, Neurodegenerative Disease, Neurology Process, Neuroscience, Neurotransmitter, Pathways and Processes, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters. .

References & Citations

1. Allderdice PW, Gardner HA, Galutira D, Lockridge O, LaDu BN, McAlpine PJ (Oct 1991) . The cloned butyrylcholinesterase (BCHE) gene maps to a single chromosome site, 3q26. Genomics 11 (2) : 452–4. 2. Jasmin L (2013-05-28) . Cholinesterase - blood. University of Maryland Medical Center. 3. Pohanka M (2013) . Butyrylcholinesterase as a biochemical marker. Bratislavské Lekárske Listy 114 (12) : 726–734.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

68462 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Cholinesterase

Subcellular Location

Secreted .

Sequence Similarities

Contains 1 CARD domain.

Protein Name

Cholinesterase

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

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