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Anti-TSG101 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

TSG101, known as Tumor susceptibility gene 101, is mapped to 11p15. The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. And the protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression.

Synonyms

Tumor susceptibility gene 101 protein; ESCRT-I complex subunit TSG101; TSG101

Gene Name

TSG101

Gene ID

7251

UniProt

Q99816

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human TSG101, identical to the related mouse and rat sequences.

Clonality

Polyclonal

Tissue Specificity

Heart, brain, placenta, lung, liver, skeletal, kidney and pancreas.

Applications

Flow Cytometry

Field of Research

Cancer, Cell Biology, Cell Cycle, Cell Cycle Inhibitors, Cell Differentiation, Epigenetics and Nuclear Signaling, Host-Virus Interaction, Interspecies Interaction, Microbiology

Purification

Immunogen affinity purified.

Form

Liquid

Function

Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) . Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. .

References & Citations

1. Entrez Gene: TSG101 tumor susceptibility gene 101. 2. Lu Q, Hope LW, Brasch M, Reinhard C, Cohen SN (June 2003) . TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation.Proc. Natl. Acad. Sci. U.S.A. 100 (13) : 7626–31. 3. Sun Z, Pan J, Hope WX, Cohen SN, Balk SP (August 1999) . Tumor susceptibility gene 101 protein represses androgen receptor transactivation and interacts with p300. Cancer 86 (4) : 689–96.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

44 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Tumor susceptibility gene 101 protein

Subcellular Location

Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Late endosome membrane; Peripheral membrane protein. Mainly cytoplasmic. Membrane-associated when active and soluble when inactive. Depending on the stage of the cell cycle, detected in the nucleus. Colocalized with CEP55 in the midbody during cytokinesis.

Sequence Similarities

Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.

Protein Name

Tumor susceptibility gene 101 protein

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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