Anti-CD59 glycoprotein CD59 Antibody Picoband® Fluoro647 Conjugated

This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. And this protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. It also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.

CD59 glycoprotein;1F5 antigen;20 kDa homologous restriction factor; HRF-20; HRF20; MAC-inhibitory protein; MAC-IP; MEM43 antigen; Membrane attack complex inhibition factor; MACIF; Membrane inhibitor of reactive lysis; MIRL; Protectin; CD59; CD59; MIC11, MIN1, MIN2, MIN3, MSK21

Atherosclerosis, Cardiovascular, Cell Type Markers, Complement, Hematopoietic Progenitors, Immunology, Innate Immunity, Protein Phosphorylation, Signal Transduction, Stem Cells, Surface Molecules, Tyrosine Kinases, Vascular Inflammation

Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.

1. Entrez Gene: CD59 molecule, complement regulatory protein. 2. Ninomiya H, Sims PJ (1992) . The human complement regulatory protein CD59 binds to the alpha-chain of C8 and to the bdomain of C9. J. Biol. Chem. 267 (19) : 13675–80.