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Anti-TRPV5 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Transient receptor potential cation channel subfamily V member 5 is a protein that in humans is encoded by the TRPV5 gene. This gene is a member of the transient receptor family and the TrpV subfamily. The calcium-selective channel encoded by this gene has 6 transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. And this protein forms homotetramers or heterotetramers and is activated by a low internal calcium level. In addition, TRPV5 is mainly expressed in kidney epithelial cells, where it plays an important role in the reabsorption of Ca2+. Genetic deletion of TRPV5 in mice leads to Ca2+ loss in the urine, and consequential hyperparathyroidism, and bone loss.

Synonyms

Transient receptor potential cation channel subfamily V member 5; TrpV5; Calcium transport protein 2; CaT2; Epithelial calcium channel 1; ECaC; ECaC1; Osm-9-like TRP channel 3; OTRPC3; TRPV5; ECAC1

Gene Name

TRPV5

Gene ID

56302

UniProt

Q9NQA5

Host

Rabbit

Reactivity

Human, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human TRPV5, different from the related mouse and rat sequences by one amino acid.

Clonality

Polyclonal

Tissue Specificity

Expressed at high levels in kidney, small intestine and pancreas, and at lower levels in testis, prostate, placenta, brain, colon and rectum. .

Applications

Flow Cytometry

Field of Research

Channels, Metabolism, Plasma Membrane, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Constitutively active calcium selective cation channel thought to be involved in Ca (2+) reabsorption in kidney and intestine. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca (2+) - dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity) . .

References & Citations

1. Clapham DE, Julius D, Montell C, Schultz G (Dec 2005) . International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels.Pharmacol. Rev. 57 (4) : 427–50. 2. Müller D, Hoenderop JG, Meij IC, van den Heuvel LP, Knoers NV, den Hollander AI et al. (Nov 2000) . Molecular cloning, tissue distribution, and chromosomal mapping of the human epithelial Ca2+ channel (ECAC1) . Genomics 67 (1) : 48–53. 3. Müller D, Hoenderop JG, Merkx GF, van Os CH, Bindels RJ (Sep 2000) . Gene structure and chromosomal mapping of human epithelial calcium channel. Biochem. Biophys. Res. Commun. 275 (1) : 47–52.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

82551 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Transient receptor potential cation channel subfamily V member 5

Subcellular Location

Apical cell membrane ; Multi-pass membrane protein . Colocalized with S100A10 and ANAX2 along the apical domain of kidney distal tubular cells (By similarity) . The expression of the glycosylated form in the cell membrane is increased in the presence of WNK3. .

Sequence Similarities

Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV5 sub-subfamily.

Protein Name

Transient receptor potential cation channel subfamily V member 5

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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