Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-STAT3 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

The transcription factor, signal transducer and activator of transcription-3 (STAT-3) is the most pleiotropic member of the signal transducer and activator of transcription (STAT) family of transcription factors and mediates pivotal responses for the cytokine family. The mouse STAT3 gene contains 24 exons and spans 30 kb. The translation initiation codon is in exon 2, and the stop codon is in exon 24. STAT3 is mapped to 17q21. It contributes to various physiological processes. Hepatic STAT-3 signaling is thus essential for normal glucose homeostasis and may provide new therapeutic targets for diabetes mellitus.

Synonyms

Signal transducer and activator of transcription 3; Acute-phase response factor; STAT3; APRF

Gene Name

STAT3

Gene ID

6774

UniProt

P40763

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human STAT3, identical to the related mouse and rat sequences.

Clonality

Polyclonal

Tissue Specificity

Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Applications

Flow Cytometry

Field of Research

Cancer, Cardiogenesis, Cardiovascular, Developmental Biology, Embryogenesis, Embryonic Stem Cells, Epigenetics and Nuclear Signaling, Hypertrophy, Intracellular, Nuclear Signaling, Nuclear Signaling Pathways, Signal Transduction, Signaling Pathway, Stem Cells, Surface Molecules, Transcription, Transcription Factors, Transcription Factors/Regulators

Purification

Immunogen affinity purified.

Form

Liquid

Function

Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6) - responsive elements identified in the promoters of various acute- phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity) . .

References & Citations

1. Bhattacharya, S.; Schindler, C. : Regulation of Stat3 nuclear export. J. Clin. Invest. 111: 553-559, 2003. 2. Inoue, H.; Ogawa, W.; Ozaki, M.; Haga, S.; Matsumoto, M.; Furukawa, K.; Hashimoto, N.; Kido, Y.; Mori, T.; Sakaue, H.; Teshigawara, K.; Jin, S.; Iguchi, H.; Hiramatsu, R.; LeRoith, D.; Takeda, K.; Akira, S.; Kasuga, M. : Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo. Nature Med. 10: 168-174, 2004. 3. Miyoshi, K.; Cui, Y.; Riedlinger, G.; Robinson, P.; Lehoczky, J.; Zon, L.; Oka, T.; Dewar, K.; Hennighausen, L. : Structure of the mouse Stat 3/5 locus: evolution from Drosophila to zebrafish to mouse. Genomics 71: 150-155, 2001.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

88068 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Signal transducer and activator of transcription 3

Subcellular Location

Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation. Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3. Identified in a complex with LYN and PAG1.

Sequence Similarities

Belongs to the transcription factor STAT family.

Protein Name

Signal transducer and activator of transcription 3

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

CI173 Rabbit Polyclonal Antibody
JOT-AP07812-01 50ul

CI173 Rabbit Polyclonal Antibody

Ask
View Details
CI173 Rabbit Polyclonal Antibody
JOT-AP07812-02 100ul

CI173 Rabbit Polyclonal Antibody

Ask
View Details
TGFB1 Rabbit pAb (APR23240N)
APR23240N-01 50 µL

TGFB1 Rabbit pAb (APR23240N)

Ask
View Details
TGFB1 Rabbit pAb (APR23240N)
APR23240N-02 100 µL

TGFB1 Rabbit pAb (APR23240N)

Ask
View Details
TGFB1 Rabbit pAb (APR23240N)
APR23240N-03 200 µL

TGFB1 Rabbit pAb (APR23240N)

Ask
View Details
CASP1 Antibody; HRP conjugated
MBS7002458-01 0.05 mg

CASP1 Antibody; HRP conjugated

Ask
View Details