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Anti-SFRS3/SRSF3 Antibody Picoband®

Boster Bio Anti-SFRS3/SRSF3 Antibody Picoband® catalog # PB9509. Tested in Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

Splicing factor, arginine/serine-rich 3, also known as SRSF3, is a protein that in humans is encoded by the SFRS3 gene. The protein encoded by this gene is a member of the serine/ arginine (SR) -rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants, one protein-coding and the other non-coding, have been found for this gene.

Synonyms

Serine/arginine-rich splicing factor 3; Pre-mRNA-splicing factor SRP20; Splicing factor, arginine/serine-rich 3; SRSF3; SFRS3, SRP20

Gene Name

SRSF3

Gene ID

6428

UniProt

P84103

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human SFRS3, identical to the related mouse and rat sequences.

Clonality

Polyclonal

Tissue Specificity

Ubiquitously expressed.

Applications

Flow Cytometry, IF, ICC, WB

Field of Research

DNA/RNA, Epigenetics and Nuclear Signaling, RNA Processing, Splicing

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

May be involved in RNA processing in relation with cellular proliferation and/or maturation. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway) ; enhances NXF1-NXT1 RNA- binding activity. RNA-binding is semi-sequence specific. .

References & Citations

1. Entrez Gene: SFRS3 splicing factor, arginine/serine-rich 3. 2. Zahler AM, Lane WS, Stolk JA, Roth MB (Jun 1992) . SR proteins: a conserved family of pre-mRNA splicing factors. Genes Dev 6 (5) : 837–47.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

19330 MW

Observed Molecular Weight

19 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Serine/arginine-rich splicing factor 3

Subcellular Location

Nucleus . Cytoplasm .

Sequence Similarities

Belongs to the splicing factor SR family.

Protein Name

Serine/arginine-rich splicing factor 3

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg NaN3.

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