Anti-SOCS4 Antibody Picoband® Fluoro594 Conjugated

Product Specifications

Background

SOCS4, also known as Suppressor of cytokine signaling 4, is mapped to 14q22.1. The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.

Synonyms

Suppressor of cytokine signaling 4; SOCS-4; Suppressor of cytokine signaling 7; SOCS-7; SOCS4; SOCS7

Gene Name

SOCS4

Gene ID

122809

UniProt

Q8WXH5

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human SOCS4 recombinant protein (Position: M291-C440) . Human SOCS4 shares 98% amino acid (aa) sequence identity with mouse SOCS4.

Clonality

Polyclonal

Tissue Specificity

Placenta, liver, and to a much smaller extent, in lung.

Applications

Flow Cytometry

Field of Research

Adapters, Cytoplasmic, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR. .

References & Citations

1. Bullock AN; Rodriguez MC; Debreczeni JE; Songyang Z; Knapp S. “Structure of the SOCS4-ElonginB/C complex reveals a distinct SOCS box interface and the molecular basis for SOCS-dependent EGFR degradation”. Structure, 2007 Nov. 2. Kobayashi D; Nomoto S; Kodera Y; Fujiwara M; Koike M; Nakayama G; Ohashi N; Nakao A. “Suppressor of cytokine signaling 4 detected as a novel gastric cancer suppressor gene using double combination array analysis”. World J Surg, 2012 Feb.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

50623 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

Gene Name Synonym

Suppressor of cytokine signaling 4

Subcellular Location

Membrane; Multi-pass membrane protein.

Sequence Similarities

Contains 1 SH2 domain.

Protein Name

Suppressor of cytokine signaling 4

Isotype

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

More Discoveries

Explore Other Products

Browse additional items from our catalog

NBP2-99609AF405 0.1 mL

Rabbit Polyclonal PSMA2 Antibody [Alexa Fluor 405]

View Details

MBS9246305-01 0.1 mL

TASK-1 Polyclonal Antibody

View Details

MBS9246305-02 5x 0.1 mL

TASK-1 Polyclonal Antibody

View Details

MBS3225969-01 0.1 mg

EYA1 Peptide - N-terminal region

View Details

MBS3225969-02 5x 0.1 mg

EYA1 Peptide - N-terminal region

View Details

EK249609 96 Well

Rat NCAM (Neural Cell Adhesion Molecule) ELISA Kit

View Details

Anti-SOCS4 Antibody Picoband® Fluoro594 Conjugated

Product Specifications

Background

Synonyms

Gene Name

Gene ID

UniProt

Host

Reactivity

Cross Reactivity

Immunogen

Clonality

Tissue Specificity

Applications

Field of Research

Purification

Form

Function

References & Citations

Storage Conditions

Calculated Molecular Weight

Specificity

Applications Notes

Gene Name Synonym

Subcellular Location

Sequence Similarities

Protein Name

Isotype

Contents

Explore Other Products

Rabbit Polyclonal PSMA2 Antibody [Alexa Fluor 405]

TASK-1 Polyclonal Antibody

TASK-1 Polyclonal Antibody

EYA1 Peptide - N-terminal region

EYA1 Peptide - N-terminal region

Rat NCAM (Neural Cell Adhesion Molecule) ELISA Kit