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Anti-SOCS4 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

SOCS4, also known as Suppressor of cytokine signaling 4, is mapped to 14q22.1. The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.

Synonyms

Suppressor of cytokine signaling 4; SOCS-4; Suppressor of cytokine signaling 7; SOCS-7; SOCS4; SOCS7

Gene Name

SOCS4

Gene ID

122809

UniProt

Q8WXH5

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human SOCS4 recombinant protein (Position: M291-C440) . Human SOCS4 shares 98% amino acid (aa) sequence identity with mouse SOCS4.

Clonality

Polyclonal

Tissue Specificity

Placenta, liver, and to a much smaller extent, in lung.

Applications

Flow Cytometry

Field of Research

Adapters, Cytoplasmic, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR. .

References & Citations

1. Bullock AN; Rodriguez MC; Debreczeni JE; Songyang Z; Knapp S. “Structure of the SOCS4-ElonginB/C complex reveals a distinct SOCS box interface and the molecular basis for SOCS-dependent EGFR degradation”. Structure, 2007 Nov. 2. Kobayashi D; Nomoto S; Kodera Y; Fujiwara M; Koike M; Nakayama G; Ohashi N; Nakao A. “Suppressor of cytokine signaling 4 detected as a novel gastric cancer suppressor gene using double combination array analysis”. World J Surg, 2012 Feb.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

50623 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Suppressor of cytokine signaling 4

Subcellular Location

Membrane; Multi-pass membrane protein.

Sequence Similarities

Contains 1 SH2 domain.

Protein Name

Suppressor of cytokine signaling 4

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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