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Anti-SOCS4 Antibody Picoband®

Boster Bio Anti-SOCS4 Antibody Picoband® catalog # PB9506. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

SOCS4, also known as Suppressor of cytokine signaling 4, is mapped to 14q22.1. The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.

Synonyms

Suppressor of cytokine signaling 4; SOCS-4; Suppressor of cytokine signaling 7; SOCS-7; SOCS4; SOCS7

Gene Name

SOCS4

Gene ID

122809

UniProt

Q8WXH5

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human SOCS4 recombinant protein (Position: M291-C440) . Human SOCS4 shares 98% amino acid (aa) sequence identity with mouse SOCS4.

Clonality

Polyclonal

Tissue Specificity

Placenta, liver, and to a much smaller extent, in lung.

Applications

WB

Field of Research

Adapters, Cytoplasmic, Signal Transduction

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR. .

References & Citations

1. Bullock AN; Rodriguez MC; Debreczeni JE; Songyang Z; Knapp S. “Structure of the SOCS4-ElonginB/C complex reveals a distinct SOCS box interface and the molecular basis for SOCS-dependent EGFR degradation”. Structure, 2007 Nov. 2. Kobayashi D; Nomoto S; Kodera Y; Fujiwara M; Koike M; Nakayama G; Ohashi N; Nakao A. “Suppressor of cytokine signaling 4 detected as a novel gastric cancer suppressor gene using double combination array analysis”. World J Surg, 2012 Feb.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

50623 MW

Observed Molecular Weight

51 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Suppressor of cytokine signaling 4

Subcellular Location

Membrane; Multi-pass membrane protein.

Sequence Similarities

Contains 1 SH2 domain.

Protein Name

Suppressor of cytokine signaling 4

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

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