Anti-SLC19A1 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Solute carrier family 19 (folate transporter), member 1, also known as SLC19A1 or RFC1, is a protein which in humans is encoded by the SLC19A1 gene. Transport of folate compounds into mammalian cells can occur via receptor-mediated or carrier-mediated mechanisms. A functional coordination between these 2 mechanisms has been proposed to be the method of folate uptake in certain cell types. Methotrexate (MTX) is an antifolate chemotherapeutic agent that is actively transported by the carrier-mediated uptake system. And RFC1 plays a role in maintaining intracellular concentrations of folate.
Synonyms
Folate transporter 1; FOLT; Intestinal folate carrier 1; IFC-1; Placental folate transporter; Reduced folate carrier protein; RFC; Solute carrier family 19 member 1; SLC19A1; FLOT1, RFC1
Gene Name
SLC19A1
Gene ID
6573
UniProt
P41440
Host
Rabbit
Reactivity
Human, Monkey, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
A synthetic peptide corresponding to a sequence in the middle region of human SLC19A1.
Clonality
Polyclonal
Tissue Specificity
Placenta, liver, and to a much smaller extent, in lung.
Applications
Flow Cytometry
Field of Research
Pathways and Processes, Signal Transduction, Vitamins/Minerals
Purification
Immunogen affinity purified.
Form
Liquid
Function
Transporter for the intake of folate. Uptake of folate in human placental choriocarcinoma cells occurs by a novel mechanism called potocytosis which functionally couples three components, namely the folate receptor, the folate transporter, and a V-type H (+) -pump.
References & Citations
1. Entrez Gene: SLC19A1 solute carrier family 19 (folate transporter), member 1. 2. Lapenta V, Sossi V, Gosset P, Vayssettes C, Vitali T, Rabatel N, Tassone F, Blouin JL, Scott HS, Antonarakis SE, Créau N, Brahe C (April 1998) . Construction of a 2.5-Mb integrated physical and gene map of distal 21q22.3. Genomics 49 (1) : 1–13. 3. Stanisławska-Sachadyn A, Mitchell LE, Woodside JV, Buckley PT, Kealey C, Young IS, Scott JM, Murray L, Boreham CA, McNulty H, Strain JJ, Whitehead AS (September 2009) . The reduced folate carrier (SLC19A1) c.80G>A polymorphism is associated with red cell folate concentrations among women. Ann. Hum. Genet. 73 (Pt 5) : 484–491.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
64868 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Folate transporter 1
Subcellular Location
Membrane; Multi-pass membrane protein.
Sequence Similarities
Belongs to the sarcoglycan alpha/epsilon family.
Protein Name
Folate transporter 1
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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