What sizes are available for Anti-PKLR Antibody Picoband® Fluoro488 Conjugated?

Anti-PKLR Antibody Picoband® Fluoro488 Conjugated is available in the following size(s): 100 µg/Vial.

Is Anti-PKLR Antibody Picoband® Fluoro488 Conjugated in stock?

Anti-PKLR Antibody Picoband® Fluoro488 Conjugated is currently made to order / not held in immediate stock. Contact us for lead time.

Do you offer custom or private-label production of this type of product?

Yes, custom antibody development and private-label production services are available. Contact our sales team to discuss your target, timeline, and quantity requirements.

What is the immunogen used to generate this antibody?

Immunogen or antigen details used to raise this antibody are listed on the product datasheet under immunogen information.

What is the recommended positive control for this assay?

A recommended positive control, where one is specified by the manufacturer, is listed on the datasheet or in the assay protocol.

Anti-PKLR Antibody Picoband® Fluoro488 Conjugated

Q: What is the catalog number for Anti-PKLR Antibody Picoband® Fluoro488 Conjugated?

The catalog number for Anti-PKLR Antibody Picoband® Fluoro488 Conjugated is PB9499-Fluoro488.

Product Specifications

Background

Pyruvate kinase isozymes R/L is an enzyme that in humans is encoded by the PKLR gene. It is mapped to 1q21. The protein encoded by this gene is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA) . Multiple transcript variants encoding different isoforms have been found for this gene.

Synonyms

Pyruvate kinase PKLR;2.7.1.40; Pyruvate kinase 1; Pyruvate kinase isozymes L/R; R-type/L-type pyruvate kinase; Red cell/liver pyruvate kinase; PKLR; PK1, PKL

Gene Name

PKLR

Gene ID

5313

UniProt

P30613

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human PKLR, different from the related mouse sequence by one amino acid, and identical to the rat sequence.

Clonality

Polyclonal

Tissue Specificity

Ubiquitous; expressed at low levels. Not detectable in a number of hepatocarcinoma cell lines.

Applications

Flow Cytometry

Field of Research

Cancer, Cancer Metabolism, Carbohydrate Metabolism, Energy Metabolism, Energy Transfer Pathways, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Metabolism Of Carbohydrates, Pathways and Processes, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Plays a key role in glycolysis. .

References & Citations

1. Entrez Gene: PKLR pyruvate kinase, liver and RBC. 2. Tani K, Fujii H, Tsutsumi H, Sukegawa J, Toyoshima K, Yoshida MC, Noguchi T, Tanaka T, Miwa S (Apr 1987) . Human liver type pyruvate kinase: cDNA cloning and chromosomal assignment. Biochem Biophys Res Commun 143 (2) : 431–8.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

61830 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

Gene Name Synonym

Pyruvate kinase PKLR

Subcellular Location

Nucleus. Nucleus, nucleolus. Chromosome, telomere. Chromosome, centromere, kinetochore. Localizes in nucleoli, at telomere speckles and to the outer plate of kinetochores. Localization to the kinetochore is mediated by its central region and depends on NDC80 and CENPE.

Sequence Similarities

Belongs to the pyruvate kinase family.

Protein Name

Pyruvate kinase PKLR

Isotype

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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