Anti-NQO1 Antibody Picoband® Fluoro647 Conjugated

This gene is a member of the NAD (P) H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. And this FAD-binding protein forms homodimers and reduces quinones to hydroquinones. In addition, this protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD) . Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

NAD (P) H dehydrogenase [quinone] 1;1.6.5.2; Azoreductase; DT-diaphorase; DTD; Menadione reductase; NAD (P) H:quinone oxidoreductase 1; Phylloquinone reductase; Quinone reductase 1; QR1; NQO1; DIA4, NMOR1

A synthetic peptide corresponding to a sequence at the C-terminus of human NQO1, different from the related mouse and rat sequences by five amino acids.

The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.

1. Entrez Gene: NQO1 NAD (P) H dehydrogenase, quinone 1. 2. Jaiswal AK (Nov 1991) . Human NAD (P) H:quinone oxidoreductase (NQO1) gene structure and induction by dioxin.Biochemistry x30 (44) : 10647–53. 3. Ross D, Siegel D (2004) . NAD (P) H:quinone oxidoreductase 1 (NQO1, DT-diaphorase), functions and pharmacogenetics. Methods in Enzymology382: 115–44.