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Anti-ICA1 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Islet cell autoantigen 1 is a protein that in humans is encoded by the ICA1 gene. It is mapped to 7p22. This gene encodes a protein with an arfaptin homology domain that is found both in the cytosol and as membrane-bound form on the Golgi complex and immature secretory granules. What’s more, this protein is believed to be an autoantigen in insulin-dependent diabetes mellitus and primary Sjogren's syndrome. Several transcript variants encoding two different isoforms have been found for this gene.

Synonyms

Islet cell autoantigen 1;69 kDa islet cell autoantigen; ICA69; Islet cell autoantigen p69; ICAp69; p69; ICA1

Gene Name

ICA1

Gene ID

3382

UniProt

Q05084

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human ICA1, identical to the related mouse and rat sequences.

Clonality

Polyclonal

Tissue Specificity

Expressed abundantly in pancreas, heart and brain with low levels of expression in lung, kidney, liver and thyroid.

Applications

Flow Cytometry

Field of Research

Autoimmune, Cell Type Marker, Immune System Diseases, Immunology, Neuron Marker, Neuroscience, Neurotransmission, Secretory Vesicles, Synapse Marker

Purification

Immunogen affinity purified.

Form

Liquid

Function

May play a role in neurotransmitter secretion. .

References & Citations

1. Entrez Gene: ICA1 islet cell autoantigen 1, 69kDa. 2. Mally MI, Cirulli V, Hayek A, Otonkoski T (Sep 1996) . ICA69 is expressed equally in the human endocrine and exocrine pancreas. Diabetologia 39 (4) : 474–80. 3. Miyazaki I, Gaedigk R, Hui MF, Cheung RK, Morkowski J, Rajotte RV, Dosch HM (Nov 1994) . Cloning of human and rat p69 cDNA, a candidate autoimmune target in type 1 diabetes.Biochim Biophys Acta 1227 (1–2) : 101–4.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

54645 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Islet cell autoantigen 1

Subcellular Location

Cytoplasm, cytosol . Golgi apparatus membrane ; Peripheral membrane protein . Cytoplasmic vesicle, secretory vesicle membrane ; Peripheral membrane protein . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Peripheral membrane protein . Predominantly cytosolic. Also exists as a membrane-bound form which has been found associated with synaptic vesicles and also with the Golgi complex and immature secretory granules.

Sequence Similarities

Belongs to the CTCF zinc-finger protein family.

Protein Name

Islet cell autoantigen 1

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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