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Anti-alpha 1 Sodium Potassium ATPase/ATP1A1 Antibody Picoband® Fluoro488 Conjugated

Selected Variant

PB9482-Fluoro488

Size: 100 µg/Vial

Product Specifications

Background

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta) . The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene.

Synonyms

Sodium/potassium-transporting ATPase subunit alpha-1; Na (+) /K (+) ATPase alpha-1 subunit;3.6.3.9; Sodium pump subunit alpha-1; ATP1A1

Gene Name

ATP1A1

Gene ID

476

UniProt

P05023

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human ATP1A1, different from the related mouse sequence by three amino acids, and from the related rat sequence by four amino acids.

Clonality

Polyclonal

Tissue Specificity

Widely expressed, especially in kidney, liver, lymph nodes and bone marrow. .

Applications

Flow Cytometry

Field of Research

ATPases, Cancer, Cancer Metabolism, Cell Type Marker, Metabolism, Neurogenesis, Neurology Process, Neuron Marker, Neuroscience, Plasma Membrane, Response To Hypoxia, Signal Transduction, Subcellular Markers, Synapse Marker, Tags & Cell Markers

Purification

Immunogen affinity purified.

Form

Liquid

Function

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

References & Citations

1. Entrez Gene: ATP1A1 ATPase, Na+/K+transporting, alpha 1 polypeptide. 2. Dunbar LA, Caplan MJ (2001) . Ion pumps in polarized cells: sorting and regulation of the Na+, K+- and H+, K+-ATPases.. J. Biol. Chem. 276 (32) : 29617–20. 3. Xie Z, Cai T (2004) . Na+-K+--ATPase-mediated signal transduction: from protein interaction to cellular function.. Mol. Interv. 3 (3) : 157–68.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

112896 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Sodium/potassium-transporting ATPase subunit alpha-1

Subcellular Location

Cell membrane; Multi-pass membrane protein. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Sequence Similarities

Belongs to the ATG14 family.

Protein Name

Sodium/potassium-transporting ATPase subunit alpha-1

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

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