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Anti-ARSA Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Arylsulfatase A (ARSA) is an enzyme that breaks down sulfatides, namely cerebroside 3-sulfate intocerebroside and sulfate. In humans, arylsulfatase A is encoded by the ARSA gene. ARSA is mapped to 22q13.33. The protein encoded by this gene hydrolyzes cerebroside sulfate to cerebroside and sulfate. Defects in this gene lead to metachromatic leucodystrophy (MLD), a progressive demyelination disease which results in a variety of neurological symptoms and ultimately death. Alternatively spliced transcript variants have been described for this gene.

Synonyms

Arylsulfatase A; ASA;3.1.6.8; Cerebroside-sulfatase; Arylsulfatase A component B; Arylsulfatase A component C; ARSA

Gene Name

ARSA

Gene ID

410

UniProt

P15289

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human ARSA, different from the related mouse sequence by six amino acids.

Clonality

Polyclonal

Tissue Specificity

Expressed in the cerebral cortex where it is localized to the postsynaptic density (PSD) . .

Applications

Flow Cytometry

Field of Research

Cancer, Cell Biology, Cell Death, Metabolism, Metabolism Processes, Neurodegenerative Disease, Neurology Process, Neuroscience, Organelles, Pathways and Processes, Signal Transduction, Subcellular Markers, Tags & Cell Markers

Purification

Immunogen affinity purified.

Form

Liquid

Function

Hydrolyzes cerebroside sulfate.

References & Citations

1. Fujii T; Kobayashi T; Honke K et al. (1992) . Proteolytic processing of human lysosomal arylsulfatase A. Biochim. Biophys. Acta 1122 (1) : 93–8. 2. Kondo R; Wakamatsu N; Yoshino H et al. (1991) .Identification of a mutation in the arylsulfatase A gene of a patient with adult-type metachromatic leukodystrophy. Am. J. Hum. Genet. 48 (5) : 971–8. 3. Matzner U, Herbst E, Hedayati KK, Lüllmann-Rauch R, Wessig C, Schröder S, Eistrup C, Möller C, Fogh J, Gieselmann V (May 2005) . Enzyme replacement improves nervous system pathology and function in a mouse model for metachromatic leukodystrophy. Hum. Mol. Genet. 14 (9) : 1139–52.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

54 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Arylsulfatase A

Subcellular Location

Lysosome.

Sequence Similarities

Belongs to the sulfatase family.

Protein Name

Arylsulfatase A

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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