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Anti-APLP1 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Amyloid-precursor-like protein 1 (APLP1) is a membrane-associated glycoprotein, whose gene is homologous to the APP gene, which has been shown to be involved in the pathogenesis of Alzheimer's disease. APLP1 is predominantly expressed in brain, particularly in the cerebral cortex postsynaptic density. The human gene has been mapped to chromosomal region 19q13.1. The gene is 11.8 kb long and contains 17 exons. APLP1 has been considered a candidate gene for CNF. All exon regions of the gene were amplified by the polymerase chain reaction and sequenced from DNA of CNF patients. No differences were observed between CNF patients and controls, suggesting that mutations in APLP1 are not involved in the etiology of CNF.

Synonyms

Amyloid-like protein 1; APLP; APLP-1; C30; APLP1

Gene Name

APLP1

Gene ID

333

UniProt

P51693

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human APLP1, different from the related mouse sequence by three amino acids.

Clonality

Polyclonal

Tissue Specificity

Expressed in the cerebral cortex where it is localized to the postsynaptic density (PSD) . .

Applications

Flow Cytometry

Field of Research

Alzheimer's Disease, Neurodegenerative Disease, Neurology Process, Neuroscience

Purification

Immunogen affinity purified.

Form

Liquid

Function

May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity) . Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I. .

References & Citations

1.Lenkkeri, U., Kestila, M., Lamerdin, J., McCready, P., Adamson, A., Olsen, A., Tryggvason, K. Structure of the human amyloid-precursor-like protein gene APLP1 at 19q13.1. Hum. Genet. 102: 192-196, 1998.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

72176 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Amyloid-like protein 1

Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Protein Name

Amyloid-like protein 1

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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