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Anti-Wnt2 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

WNT2, also known as Wingless-type MMTV integration site family, member 2, is a human gene. This gene is a member of the WNT gene family. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Alternatively spliced transcript variants have been identified for this gene.

Synonyms

Protein Wnt-2; Int-1-like protein 1; Int-1-related protein; IRP; WNT2; INT1L1, IRP

Gene Name

WNT2

Gene ID

7472

UniProt

P09544

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human Wnt2, different from the related mouse sequence by two amino acids.

Clonality

Polyclonal

Tissue Specificity

Expressed in brain in the thalamus, in fetal and adult lung and in placenta. .

Applications

Flow Cytometry

Field of Research

Cancer, Oncoproteins/Suppressors, Secreted, Signal Transduction, Signaling Pathways, Stem Cells, Tumor Suppressors

Purification

Immunogen affinity purified.

Form

Liquid

Function

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.

References & Citations

1. Entrez Gene: WNT2 wingless-type MMTV integration site family, member 2 2. Wainwright BJ, Scambler PJ, Stanier P, Watson EK, Bell G, Wicking C, Estivill X, Courtney M, Boue A, Pedersen PS (June 1988) . Isolation of a human gene with protein sequence similarity to human and murine int-1 and the Drosophila segment polarity mutant wingless. EMBO J. 7 (6) : 1743–8.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

40418 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Protein Wnt-2

Subcellular Location

Secreted, extracellular space, extracellular matrix.

Sequence Similarities

Belongs to the Wnt family.

Protein Name

Protein Wnt-2

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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