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Anti-Wnt1 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Wingless-type MMIV integration site family, member 1 is a protein that in humans is encoded by the WNT1 gene. This gene is a member of the WNT gene family. The gene was assigned to human chromosome 12q13.12. The WNT gene family consists of structurally related genes that encode secreted signaling proteins. The Wnt1 protein functions in the induction of the mesencephalon and cerebellum. However, the gene mutations might not have a significant role in Joubert syndrome.

Synonyms

Proto-oncogene Wnt-1; Proto-oncogene Int-1 homolog; WNT1; INT1

Gene Name

WNT1

Gene ID

7471

UniProt

P04628

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human Wnt1, identical to the related mouse and rat sequences.

Clonality

Polyclonal

Tissue Specificity

Expressed predominantly in the thymus. Also found, to a much lesser extent, in the spleen. .

Applications

Flow Cytometry

Field of Research

Cancer, Oncoproteins/Suppressors, Secreted, Signaling Pathways, Stem Cells, Surface Molecules, Tumor Suppressors

Purification

Immunogen affinity purified.

Form

Liquid

Function

Ligand for members of the frizzled family of seven transmembrane receptors. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters. Has a role in osteoblast function and bone development. .

References & Citations

1. Arheden K, Mandahl N, Strombeck B, Isaksson M, Mitelman F (May 1988) . Chromosome localization of the human oncogene INT1 to 12q13 by in situ hybridization. Cytogenet Cell Genet 47 (1–2) : 86–87. 2. Entrez Gene: WNT1 wingless-type MMTV integration site family, member 1. 3. Van Ooyen A, Kwee V, Nusse R (Jan 1986) . The nucleotide sequence of the human int-1 mammary oncogene; evolutionary conservation of coding and non-coding sequences. EMBO J 4 (11) : 2905–9.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

40982 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Proto-oncogene Wnt-1

Subcellular Location

Secreted, extracellular space, extracellular matrix.

Sequence Similarities

Belongs to the Wnt family.

Protein Name

Proto-oncogene Wnt-1

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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