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Anti-Vitronectin/VTN Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Vitronectin, also known as VTN, is a protein that in humans is encoded by the VTN gene. The protein encoded by this gene is a member of the pexin family. It is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond. Also vitronectin serves to regulate proteolysis initiated by plasminogen activation. In addition, vitronectin is a component of platelets and is, thus, involved in hemostasis.

Synonyms

Vitronectin; VN; S-protein; Serum-spreading factor; V75; Vitronectin V65 subunit; Vitronectin V10 subunit; Somatomedin-B; VTN

Gene Name

VTN

Gene ID

7448

UniProt

P04004

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human Vitronectin, different from the related mouse sequence by two amino acids.

Clonality

Polyclonal

Tissue Specificity

Plasma.

Applications

Flow Cytometry

Field of Research

Actin Binding Proteins, Actin, etc., Cytoskeleton, Cytoskeleton/ECM, Microfilaments, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.

References & Citations

1. Entrez Gene: M Vitronectin. 2. Jenne D, Stanley KK (October 1987) . Nucleotide sequence and organization of the human S-protein gene: repeating peptide motifs in the pexin family and a model for their evolution. Biochemistry 26 (21) : 6735–42. 3. Preissner KT, Seiffert D (January 1998) .Role of vitronectin and its receptors in haemostasis and vascular remodeling (– SCHOLAR SEARCH) . Thromb. Res. 89 (1) : 1–21.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

54306 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Vitronectin

Subcellular Location

Secreted, extracellular space.

Sequence Similarities

Contains 4 hemopexin repeats.

Protein Name

Vitronectin

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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