Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-TLR5 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

TLR5 encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.

Synonyms

Toll-like receptor 5; Toll/interleukin-1 receptor-like protein 3; TLR5; TIL3

Gene Name

TLR5

Gene ID

7100

UniProt

O60602

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human TLR5, different from the related mouse sequence by five amino acids.

Clonality

Polyclonal

Tissue Specificity

Highly expressed in ovary and in peripheral blood leukocytes, especially in monocytes, less in CD11c+ immature dendritic cells. Also detected in prostate and testis.

Applications

Flow Cytometry

Field of Research

Immunoglobulins, Immunology, Innate Immunity, Macrophage/Inflammation, Receptors, TLR Signaling

Purification

Immunogen affinity purified.

Form

Liquid

Function

Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. .

References & Citations

1. Entrez Gene: TLR5 toll-like receptor 5. 2. Hayashi F, Smith KD, Ozinsky A, Hawn TR, Yi EC, Goodlett DR, Eng JK, Akira S, Underhill DM, Aderem A (April 2001) . The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature 410 (6832) : 1099–1103. 3. Smith KD, Andersen-Nissen E, Hayashi F, Strobe K, Bergman MA, Barrett SL, Cookson BT, Aderem A (December 2003) . Toll-like receptor 5 recognizes a conserved site on flagellin required for protofilament formation and bacterial motility. Nature Immunology 4 (12) : 1247–53.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

97834 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Toll-like receptor 5

Subcellular Location

Membrane ; Single-pass type I membrane protein .

Sequence Similarities

Belongs to the Toll-like receptor family.

Protein Name

Toll-like receptor 5

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

AdmiRa-Off-hsa-miR-6820-5p Virus
mh7316 1.0 mL

AdmiRa-Off-hsa-miR-6820-5p Virus

Ask
View Details
Human CXCR3 (CXC-Chemokine Receptor 3) ELISA Kit
EKE63167 96 Tests

Human CXCR3 (CXC-Chemokine Receptor 3) ELISA Kit

Ask
View Details
Protein FAM101A (FAM101A) Human ELISA Kit
G2775 96 Tests

Protein FAM101A (FAM101A) Human ELISA Kit

Ask
View Details
Atomic model , 60 Balls
210010A 1 Each

Atomic model , 60 Balls

Ask
View Details
BURETTES, STRAIGHT BORE GLASS STOPCOCK WITH SCREW THREAD, CLASS 'A'
2061836/6 1 Each

BURETTES, STRAIGHT BORE GLASS STOPCOCK WITH SCREW THREAD, CLASS 'A'

Ask
View Details