Anti-Cyclin A2/CCNA2 Antibody Picoband® Fluoro647 Conjugated

Cyclin A2, known as CCNA2, is mapped to 4q27. The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions. And Cyclin A2 is synthesized at the onset of S phase and localizes to the nucleus, where the cyclin A2-CDK2 complex is implicated in the initiation and progression of DNA synthesis. Phosphorylation of CDC6 and MCM4 by the cyclin A2-CDK2 complex prevents re-replication of DNA during the cell cycle.

E.coli-derived human Cyclin A2 recombinant protein (Position: A10-K168) . Human Cyclin A2 shares 74.5% amino acid (aa) sequence identity with mouse Cyclin A2.

1. Gong D, Ferrell JE (Sep 2010) . The roles of cyclin A2, B1, and B2 in early and late mitotic events. Mol. Biol. Cell 21 (18) : 3149–61. 2. Yam CH, Fung TK, Poon RY (Aug 2002) . Cyclin A in cell cycle control and cancer. Cell. Mol. Life Sci. 59 (8) : 1317–26.