Anti-RANK/TNFRSF11A Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Receptor Activator of Nuclear Factor κ B (RANK), also known as TRANCE Receptor, is a type I membrane protein that is expressed on the surface of osteoclasts and is involved in their activation upon ligand binding. RANK is also expressed on dendritic cells and facilitates immune signaling.RANKL (Receptor Activator for Nuclear Factor κ B Ligand) is found on the surface of stromal cells, osteoblasts, and T cells. By analysis of somatic cell and radiation hybrid panels, Anderson et al. (1997) mapped the RANK gene to 18q22.1.
Synonyms
Tumor necrosis factor receptor superfamily member 11A; Osteoclast differentiation factor receptor; ODFR; Receptor activator of NF-KB; CD265; Tnfrsf11a; Rank
Gene Name
Tnfrsf11a
Gene ID
8792
UniProt
O35305
Host
Rabbit
Reactivity
Mouse
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E. coli-derived mouse RANK recombinant protein (Position: C35-S214) . Mouse RANK shares 95.6% amino acid (aa) sequence identity with rat RANK.
Clonality
Polyclonal
Tissue Specificity
Ubiquitous expression with high levels in trabecular bone, thymus, small intestine, lung, brain and kidney. Weakly expressed in spleen and bone marrow.
Applications
Flow Cytometry
Field of Research
Adapters, Atherosclerosis, Cardiovascular, Cytokines, Cytoskeleton/ECM, Extracellular Matrix, Growth Factors/Hormones, Immunology, Innate Immunity, Signal Transduction, Structures, TNF Superfamily, Transmembrane, Vascular Inflammation
Purification
Immunogen affinity purified.
Form
Liquid
Function
Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells. .
References & Citations
1. Suda T, Takahashi N, Udagawa N, Jimi E, Gillespie MT, Martin TJ (1999) . Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocr. Rev. 20 (3) : 345–57. 2. Theill LE, Boyle WJ, Penninger JM (2002) . RANK-L and RANK: T cells, bone loss, and mammalian evolution. Annu. Rev. Immunol. 20: 795–823. 3. Wong BR, Josien R, Choi Y (1999) . TRANCE is a TNF family member that regulates dendritic cell and osteoclast function. J. Leukoc. Biol. 65 (6) : 715–24.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
66621 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Tumor necrosis factor receptor superfamily member 11A
Subcellular Location
Cell membrane ; Single-pass type I membrane protein .
Sequence Similarities
Belongs to the resistin/FIZZ family.
Protein Name
Tumor necrosis factor receptor superfamily member 11A
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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