Anti-Syntaxin 1a/STX1A Antibody Picoband® Fluoro594 Conjugated
Product Specifications
Background
Syntaxin-1A is a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein) -Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc) . Syntaxins bind synaptotagminin a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. Syntaxin-1A is a key protein in ion channel regulation and synaptic exocytosis.
Synonyms
Syntaxin-1A; Neuron-specific antigen HPC-1; STX1A; STX1
Gene Name
STX1A
Gene ID
6804
UniProt
Q16623
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human Syntaxin 1a, different from the related mouse and rat sequences by one amino acid.
Clonality
Polyclonal
Tissue Specificity
Isoform 1 is highly expressed in embryonic spinal chord and ganglia and in adult cerebellum and cerebral cortex. Isoform 2 is expressed in heart, liver, fat, skeletal muscle, kidney and brain. .
Applications
Flow Cytometry
Field of Research
Vesicle Transport
Purification
Immunogen affinity purified.
Form
Liquid
Function
Plays a role in hormone and neurotransmitter exocytosis (By similarity) . Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca (2+) - regulation of exocytosis acrosomal reaction in sperm. .
References & Citations
1. Entrez Gene: STX1A syntaxin 1A (brain) . 2. Bennett MK, García-Arrarás JE, Elferink LA, Peterson K, Fleming AM, Hazuka CD, Scheller RH (September 1993) . The syntaxin family of vesicular transport receptors.Cell 74 (5) : 863–73.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
33023 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Syntaxin-1A
Subcellular Location
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Single-pass type IV membrane protein . Cell junction, synapse, synaptosome . Cell membrane . Colocalizes with KCNB1 at the cell membrane. .
Sequence Similarities
Belongs to the syntaxin family.
Protein Name
Syntaxin-1A
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
