Anti-SOX1 Antibody Picoband® Fluoro550 Conjugated
Product Specifications
Background
SOX1 (for Sex determining region Y-box 1), located in 13q34, is a transcription factor in the Sox protein family. It means that this intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. In mice, a similar protein regulates the gamma-crystallin genes and is essential for lens development. SOX1 expression is restricted to neuroectodermin the tetrapod embryo. It is expressed particularly in the ventral striatum.
Synonyms
Transcription factor SOX-1; SOX1
Gene Name
SOX1
Gene ID
6656
UniProt
O00570
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
A synthetic peptide corresponding to a sequence in the middle region of Human SOX1, identical to the related mouse sequence.
Clonality
Polyclonal
Tissue Specificity
Mainly expressed in the developing central nervous system.
Applications
Flow Cytometry
Field of Research
Developmental Families, Domain Families, Epigenetics and Nuclear Signaling, Intracellular, Neural Stem Cells, Neurogenesis, Neurology Process, Neuroscience, Stem Cells, Transcription
Purification
Immunogen affinity purified.
Form
Liquid
Function
Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity) . .
References & Citations
1. Guth SI, Wegner M (October 2008) . Having it both ways: Sox protein function between conservation and innovation. Cell. Mol. Life Sci. 65 (19) : 3000–18. 2. Jump up^ Nitta KR, Takahashi S, Haramoto Y, Fukuda M, Onuma Y, Asashima M (December 2006) . Expression of Sox1 during Xenopus early embryogenesis. Biochem. Biophys. Res. Commun. 351 (1) : 287–93.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
39023 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Transcription factor SOX-1
Subcellular Location
Nucleus .
Sequence Similarities
Belongs to the Cu-Zn superoxide dismutase family.
Protein Name
Transcription factor SOX-1
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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