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Anti-Superoxide Dismutase 1/SOD1 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Superoxide dismutases (SOD) are a class of enzymes that catalyze the dismutation of superoxide into oxygen and hydrogen peroxide. As such, they are an important antioxidant defense in nearly all cells exposed to oxygen. One of the exceedingly rare exceptions is Lactobacillus plantarum and related lactobacilli, which use a different mechanism.Cu, Zn-SOD was found widely distributed in the cell cytosol and in the cell nucleus, consistent with it being a soluble cytosolic protein. Mitochondria and secretory compartments did not label for this protein. In human cells, peroxisomes showed a labeling density slightly less than that of cytoplasm.

Synonyms

Superoxide dismutase [Cu-Zn];1.15.1.1; Superoxide dismutase 1; hSod1; SOD1

Gene Name

SOD1

Gene ID

6647

UniProt

P00441

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of Human SOD1, different from the related mouse and rat sequences by two amino acids.

Clonality

Polyclonal

Tissue Specificity

High expression in heart, placenta, lung, kidney and prostate.

Applications

Flow Cytometry

Field of Research

Cancer, Cancer Metabolism, Cell Biology, Chaperones, Heat Shock Proteins, Metabolism, Oxidative Stress, Pathways and Processes, Protein Trafficking, Redox Metabolism, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

References & Citations

1. Crapo, J. D., Oury, T., Rabouille, C., Slot, J. W., Chang, L.-Y. Copper, zinc superoxide dismutase is primarily a cytosolic protein in human cells. Proc. Nat. Acad. Sci. 89: 10405-10409, 1992.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

16 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Superoxide dismutase [Cu-Zn]

Subcellular Location

Cytoplasm. Nucleus. Predominantly cytoplasmic; the pathogenic variants ALS1 Arg-86 and Ala-94 gradually aggregates and accumulates in mitochondria.

Sequence Similarities

Belongs to the Cu-Zn superoxide dismutase family.

Protein Name

Superoxide dismutase [Cu-Zn]

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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