Anti-SOCS2 Antibody Picoband® Fluoro488 Conjugated

Suppressor of cytokine signaling 2 is a protein that in humans is encoded by the SOCS2 gene. This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signalling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon-gamma (IFN-gamma) . The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor 1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling. By cytogenetic and radiation hybrid mapping, Yandava et al. (1999) mapped the SOCS2 gene to chromosome 12q21.3-q23.

E.coli-derived human SOCS2 recombinant protein (Position: R96-V198) . Human SOCS2 shares 96.1% and 95.1% amino acid (aa) sequence identity with mouse and rat SOCS2, respectively.

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

1. Entrez Gene: SOCS2 suppressor of cytokine signaling 2. 2. Dey BR, Spence SL, Nissley P, Furlanetto RW (September 1998) . Interaction of human suppressor of cytokine signaling (SOCS) -2 with the insulin-like growth factor-I receptor. J. Biol. Chem. 273 (37) : 24095–101. 3. Greenhalgh CJ, Bertolino P, Asa SL, Metcalf D, Corbin JE, Adams TE, Davey HW, Nicola NA, Hilton DJ, Alexander WS (June 2002) . Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2) -deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b) . Mol. Endocrinol. 16 (6) : 1394–406. 4. Masuhara M, Sakamoto H, Matsumoto A, Suzuki R, Yasukawa H, Mitsui K, Wakioka T, Tanimura S, Sasaki A, Misawa H, Yokouchi M, Ohtsubo M, Yoshimura A (Nov 1997) . Cloning and characterization of novel CIS family genes. Biochem Biophys Res Commun 239 (2) : 439–46. 5. Minamoto S, Ikegame K, Ueno K, Narazaki M, Naka T, Yamamoto H, Matsumoto T, Saito H, Hosoe S, Kishimoto T (Sep 1997) . Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3. Biochem Biophys Res Commun 237 (1) : 79–83.