Anti-CD62P/SELP Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
CD62P is also known as SELP or P-selectin. This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented.?
Synonyms
P-selectin; CD62 antigen-like family member P; Granule membrane protein 140; GMP-140; Leukocyte-endothelial cell adhesion molecule 3; LECAM3; Platelet activation dependent granule-external membrane protein; PADGEM; CD62P; SELP; GMRP, GRMP
Gene Name
SELP
Gene ID
6403
UniProt
P16109
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human CD62P recombinant protein (Position: W42-G271) . Human CD62P shares 75.2% and 75.7% amino acid (aa) sequence identity with mouse and rat CD62P, respectively.
Clonality
Polyclonal
Tissue Specificity
Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface.
Applications
Flow Cytometry
Field of Research
Adaptive Immunity, Angiogenesis, Atherosclerosis, Cardiovascular, Cell Adhesion Molecules, Cell Type Markers, Hematopoietic Progenitors, Immunology, Myeloid, Platelets, Stem Cells, Vascular Inflammation
Purification
Immunogen affinity purified.
Form
Liquid
Function
Ca (2+) -dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1. .
References & Citations
1. Gremmel T, et al. Impact of diabetes on platelet activation in different manifestations of atherosclerosis. Swiss Med Wkly, 2013 May 28. 2. Kutlar A, et al. Cellular adhesion and the endothelium: P-selectin. Hematol Oncol Clin North Am, 2014 Apr.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
90 kDa
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
P-selectin
Subcellular Location
Membrane; Single-pass type I membrane protein.
Sequence Similarities
Belongs to the selectin/LECAM family.
Protein Name
P-selectin
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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