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Anti-SFRP2 Antibody Picoband® Fluoro594 Conjugated

Product Specifications

Background

SFRP2 is also known as FRP-2, SARP1 or SDF-5. It is Expressed in adipose tissue, heart, brain, skeletal muscle, pancreas, thymus, prostate, testis, ovary, small intestine and colon. Highest levels in adipose tissue, small intestine and colon. This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer.?

Synonyms

Secreted frizzled-related protein 2; FRP-2; sFRP-2; Secreted apoptosis-related protein 1; SARP-1; SFRP2; FRP2, SARP1; FKSG12, UNQ361/PRO697

Gene Name

SFRP2

Gene ID

6423

UniProt

Q96HF1

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human SFRP2 recombinant protein (Position: L104-C295) . Human SFRP2?shares?99%?amino?acid? (aa) ?sequence?identity?with mouse SFRP2.

Clonality

Polyclonal

Tissue Specificity

Expressed in adipose tissue, heart, brain, skeletal muscle, pancreas, thymus, prostate, testis, ovary, small intestine and colon. Highest levels in adipose tissue, small intestine and colon. .

Applications

Flow Cytometry

Field of Research

Angiogenesis, Cancer, Cardiogenesis, Cardiovascular, Invasion/Microenvironment, Mesenchymal Stem Cells, Secreted, Signaling Pathways, Stem Cells, Transcription Factors/Regulators

Purification

Immunogen affinity purified.

Form

Liquid

Function

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis.

References & Citations

1. Hao XW, et al. Epigenetic inactivation of secreted frizzled-related protein 2 in esophageal squamous cell carcinoma. World J Gastroenterol, 2012 Feb 14. 2. O'Hurley G, et al. The role of secreted frizzled-related protein 2 expression in prostate cancer. Histopathology, 2011 Dec. 3. Sui C, et al. Variation risks of SFRP2 hypermethylation between precancerous disease and colorectal cancer. Tumour Biol, 2014 Oct.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

33490 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Secreted frizzled-related protein 2

Subcellular Location

Secreted .

Sequence Similarities

Belongs to the secreted frizzled-related protein (sFRP) family.

Protein Name

Secreted frizzled-related protein 2

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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