Anti-Prolactin/PRL Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Prolactin (PRL), also known as luteotropic hormone or luteotropin, is a protein that in humans is best known for its role in enabling female mammals to produce milk. This gene encodes the anterior pituitary hormone prolactin. This secreted hormone is a growth regulator for many tissues, including cells of the immune system. It may also play a role in cell survival by suppressing apoptosis, and it is essential for lactation. Alternative splicing results in multiple transcript variants that encode the same protein.
Synonyms
Prolactin; PRL; PRL
Gene Name
PRL
Gene ID
5617
UniProt
P01236
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human Prolactin recombinant protein (Position: L29-227C) . Human Prolactin?shares?60%?and 63% amino?acid? (aa) ?sequence?identity?with mouse?and?rat Prolactin, respectively.
Clonality
Polyclonal
Tissue Specificity
Highly expressed in fibroblasts, some expression in T- and B-lymphocytes, and little or no expression in Burkitt's lymphoma cell lines. Expressed in many hormone- independent mammary carcinoma cell lines. .
Applications
Flow Cytometry
Field of Research
Growth Factors/Hormones, Lipid Metabolism, Metabolism, Protein Phosphorylation, Receptor Tyrosine Kinases, Signal Transduction, Tyrosine Kinases
Purification
Immunogen affinity purified.
Form
Liquid
Function
Prolactin acts primarily on the mammary gland by promoting lactation.
References & Citations
1. Correale J, et al. Role of prolactin in B cell regulation in multiple sclerosis. J Neuroimmunol, 2014 Apr 15. 2. De Kuijper GM, et al. Effects of discontinuation of long-term used antipsychotics on prolactin and bone turnover markers in patients with intellectual disability. J Clin Psychopharmacol, 2014 Feb. 3. Zaga-Clavellina V, et al. The potential role of prolactin as a modulator of the secretion of proinflammatory mediators in chorioamniotic membranes in term human gestation. Am J Obstet Gynecol, 2014 Jul.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
25876 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Prolactin
Subcellular Location
Secreted.
Sequence Similarities
Belongs to the somatotropin/prolactin family.
Protein Name
Prolactin
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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