Anti-RBP4 Antibody Picoband® Fluoro488 Conjugated

RBP4 is also known as RDCCAS. This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells.

Retinol-binding protein 4; Plasma retinol-binding protein; PRBP; RBP; Plasma retinol-binding protein (1-182) ; Plasma retinol-binding protein (1-181) ; Plasma retinol-binding protein (1-179) ; Plasma retinol-binding protein (1-176) ; RBP4; PRO2222

E.coli-derived human RBP4 recombinant protein (Position: E19-201L) . Human RBP4 shares 86% amino acid (aa) sequence identity with both mouse and rat RBP4.

Highly expressed in fibroblasts, some expression in T- and B-lymphocytes, and little or no expression in Burkitt's lymphoma cell lines. Expressed in many hormone- independent mammary carcinoma cell lines. .

Atherosclerosis, Cancer, Cardiovascular, Cofactors, Vitamins/Minerals, Diabetes, Diabetes-associated, Heart Disease, Metabolism, Pathways and Processes, Serum Proteins, Signal Transduction, Vitamins/Minerals

Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.

1. Cubedo J, et al. Retinol-binding protein 4 levels and susceptibility to ischaemic events in men. Eur J Clin Invest, 2014. 2. Li F, et al. Retinol-binding protein 4 as a novel risk factor for cardiovascular disease in patients with coronary artery disease and hyperinsulinemia. Am J Med Sci, 2014 Dec. 3. Saucedo R, et al. RBP4 gene variants are associated with insulin resistance in women with previous gestational diabetes. Dis Markers, 2014.