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Anti-RBP4 Antibody Picoband®

Boster Bio Anti-RBP4 Antibody Picoband® catalog # PB9360. Tested in ELISA, IF, IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

RBP4 is also known as RDCCAS. This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells.

Synonyms

Retinol-binding protein 4; Plasma retinol-binding protein; PRBP; RBP; Plasma retinol-binding protein (1-182) ; Plasma retinol-binding protein (1-181) ; Plasma retinol-binding protein (1-179) ; Plasma retinol-binding protein (1-176) ; RBP4; PRO2222

Gene Name

RBP4

Gene ID

5950

UniProt

P02753

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human RBP4 recombinant protein (Position: E19-201L) . Human RBP4 shares 86% amino acid (aa) sequence identity with both mouse and rat RBP4.

Clonality

Polyclonal

Tissue Specificity

Highly expressed in fibroblasts, some expression in T- and B-lymphocytes, and little or no expression in Burkitt's lymphoma cell lines. Expressed in many hormone- independent mammary carcinoma cell lines. .

Applications

ELISA, IF, IHC, WB

Field of Research

Atherosclerosis, Cancer, Cardiovascular, Cofactors, Vitamins/Minerals, Diabetes, Diabetes-associated, Heart Disease, Metabolism, Pathways and Processes, Serum Proteins, Signal Transduction, Vitamins/Minerals

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.

References & Citations

1. Cubedo J, et al. Retinol-binding protein 4 levels and susceptibility to ischaemic events in men. Eur J Clin Invest, 2014. 2. Li F, et al. Retinol-binding protein 4 as a novel risk factor for cardiovascular disease in patients with coronary artery disease and hyperinsulinemia. Am J Med Sci, 2014 Dec. 3. Saucedo R, et al. RBP4 gene variants are associated with insulin resistance in women with previous gestational diabetes. Dis Markers, 2014.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

23 kDa

Observed Molecular Weight

23 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Retinol-binding protein 4

Subcellular Location

Secreted.

Sequence Similarities

Belongs to the calycin superfamily. Lipocalin family.

Protein Name

Retinol-binding protein 4

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

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