Anti-MASPIN/SERPINB5 Antibody Picoband® Fluoro550 Conjugated
Product Specifications
Background
SERPINB5 is also known as PI5 or maspin. Maspin (mammary serine protease inhibitor) is a protein that in humans is encoded by the SERPINB5 gene. Maspin is expressed in the skin, prostate, testis, intestine, tongue, lung, and the thymus. Maspin is a member of the serpin superfamily of serine protease inhibitors.[1] The primary function of most members of this family is to regulate the breakdown of proteins by inhibiting the catalytic activity of proteinases. Through this mechanism of action, serpins regulate a number of cellular processes includingphagocytosis, coagulation, and fibrinolysis.
Synonyms
Serpin B5; Maspin; Peptidase inhibitor 5; PI-5; SERPINB5; PI5
Gene Name
SERPINB5
Gene ID
5268
UniProt
P36952
Host
Rabbit
Reactivity
Human, Mouse
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human MASPIN recombinant protein (Position: M1-A350) . Human MASPIN shares 88% and 89% amino acid (aa) sequence identity with mouse and rat MASPIN, respectively.
Clonality
Polyclonal
Tissue Specificity
Normal mammary epithelial cells.
Applications
Flow Cytometry
Field of Research
Cancer, Cell Type Markers, Oncoproteins/Suppressors, Tags & Cell Markers, Tumor Associated, Tumor Suppressors
Purification
Immunogen affinity purified.
Form
Liquid
Function
Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
References & Citations
1. Blandamura S, et al. Maspin expression, subcellular localization and clinicopathological correlation in endometrial hyperplasia and endometrial adenocarcinoma. Histol Histopathol, 2014 Jun. 2. Taskiran C, et al. Maspin expression in endometrial hyperplasia and carcinoma, and its relation with angiogenesis. Eur J Gynaecol Oncol, 2014. 3. Triulzi T, et al. Maspin influences response to doxorubicin by changing the tumor microenvironment organization. Int J Cancer, 2014 Jun 15.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
42100 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Serpin B5
Subcellular Location
Secreted, extracellular space.
Sequence Similarities
Belongs to the serpin family. Ov-serpin subfamily.
Protein Name
Serpin B5
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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