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Anti-SerpinB2 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

SERPINB2 is also known as PAI or PAI2. Plasminogen activator inhibitor-2 (placental PAI) is acoagulation factor that inactivates tPA and urokinase. It is present in most cells, especially monocytes/macrophages. PAI-2 exists in two forms, a 60-kDa extracellular glycosylated form and a 43-kDa intracellular form. It is present only at detectable quantities in blood during pregnancy, as it is produced by the placenta, and may explain partially the increased rate of thrombosisduring pregnancy. The majority of expressed PAI-2 remains unsecreted due to the presence of an inefficient internal signal peptide.

Synonyms

Plasminogen activator inhibitor 2; PAI-2; Monocyte Arg-serpin; Placental plasminogen activator inhibitor; Serpin B2; Urokinase inhibitor; SERPINB2; PAI2, PLANH2

Gene Name

SERPINB2

Gene ID

5055

UniProt

P05120

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human SerpinB2 recombinant protein (Position: M1-K180) . Human SerpinB2 shares 70% and 66% amino acid (aa) sequence identity with mouse and rat SerpinB2, respectively.

Clonality

Polyclonal

Tissue Specificity

Plasma. .

Applications

Flow Cytometry

Field of Research

Cell Biology, Immunology, Innate Immunity, Macrophage/Inflammation, Protease Inhibitors, Proteolysis/Ubiquitin

Purification

Immunogen affinity purified.

Form

Liquid

Function

Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell- derived PAI-1.

References & Citations

1. Corsetti JP, et al. Plasminogen activator inhibitor-2 polymorphism associates with recurrent coronary event risk in patients with high HDL and C-reactive protein levels. PLoS One, 2013. 2. Huang Z, et al. SERPINB2 down-regulation contributes to chemoresistance in head and neck cancer. Mol Carcinog, 2014 Oct. 3. Jin Y, et al. Expression of plasminogen activator inhibitor-2 is negatively associated with invasive potential in hepatocellular carcinoma cells. Chin Med Sci J, 2013 Mar. 4. Zhou L, et al. Low expression of PAI-2 as a novel marker of portal vein tumor thrombosis and poor prognosis in hepatocellular carcinoma. World J Surg, 2013 Mar.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

46596 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Plasminogen activator inhibitor 2

Subcellular Location

Cytoplasm. Secreted, extracellular space.

Sequence Similarities

Belongs to the semaphorin family.

Protein Name

Plasminogen activator inhibitor 2

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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