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Anti-PSCA Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

PSCA is also known as PRO232. This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene includes a polymorphism that results in an upstream start codon in some individuals; this polymorphism is thought to be associated with a risk for certain gastric and bladder cancers. Alternative splicing results in multiple transcript variants.

Synonyms

Prostate stem cell antigen; PSCA; UNQ206/PRO232

Gene Name

PSCA

Gene ID

8000

UniProt

O43653

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human PSCA recombinant protein (Position: L21-S95) . Human PSCA shares 66% amino acid (aa) sequence identity with mouse PSCA.

Clonality

Polyclonal

Tissue Specificity

Highly expressed in prostate (basal, secretory and neuroendocrine epithelium cells) . Also found in bladder (transitional epithelium), placenta (trophoblasts), stomach (neuroendocrine cells), colon (neuroendocrine cells) and kidney (collecting ducts) . Overexpressed in prostate cancers and expression is correlated with tumor stage, grade and androgen- independence. Highly expressed in prostate cancer bone metastases. Expressed in gastric epithelial cells, mainly in the isthmus (at protein level) . Not detected in normal intestinal epithelium (at protein level) . .

Applications

Flow Cytometry

Field of Research

Cell Type Markers, Intracellular, Stem Cells, Tags & Cell Markers, Tumor Associated

Purification

Immunogen affinity purified.

Form

Liquid

Function

May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro. .

References & Citations

1. Hillerdal V, et al. Systemic treatment with CAR-engineered T cells against PSCA delays subcutaneous tumor growth and prolongs survival of mice. BMC Cancer, 2014 Jan 18. 2. Taeb J, et al. Expression of prostate stem cell antigen (PSCA) in prostate cancer: a tissue microarray study of Iranian patients. Pathol Res Pract, 2014 Jan.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

12912 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Prostate stem cell antigen

Subcellular Location

Cell membrane; Lipid-anchor, GPI-anchor.

Sequence Similarities

Contains 1 UPAR/Ly6 domain.

Protein Name

Prostate stem cell antigen

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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