Anti-Peroxiredoxin 6/PRDX6 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
PRDX6 is also known as PRX, p29 or AOP2. The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H (2) O (2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury.
Synonyms
Peroxiredoxin-6;1.11.1.15;1-Cys peroxiredoxin;1-Cys PRX;24 kDa protein; Acidic calcium-independent phospholipase A2; aiPLA2;3.1.1.-; Antioxidant protein 2; Liver 2D page spot 40; Non-selenium glutathione peroxidase; NSGPx;1.11.1.9; Red blood cells page spot 12; PRDX6; AOP2, KIAA0106
Gene Name
PRDX6
Gene ID
9588
UniProt
P30041
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human Peroxiredoxin 6 recombinant protein (Position: E15-P224) . Human Peroxiredoxin 6 shares 90% and 91% amino acid (aa) sequence identity with mouse and rat Peroxiredoxin 6, respectively.
Clonality
Polyclonal
Tissue Specificity
Synthesized in numerous tissues (including tumors) and secreted into most extracellular body fluids, such as plasma, uterine fluid, saliva, gingival crevicular fluid, tears, seminal fluid, and milk.
Applications
Flow Cytometry
Field of Research
Atherosclerosis, Cancer, Cancer Metabolism, Cardiovascular, Cell Biology, Heart Disease, Lipid Metabolism, Metabolism, Mitochondrial Markers, Mitochondrial Metabolism, Oxidative Stress, Pathways and Processes, Redox Metabolism, Signal Transduction, Vascular Inflammation
Purification
Immunogen affinity purified.
Form
Liquid
Function
Involved in redox regulation of the cell. Can reduce H (2) O (2) and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury.
References & Citations
1. Ambruso DR, et al. Peroxiredoxin 6 translocates to the plasma membrane during neutrophil activation and is required for optimal NADPH oxidase activity. Biochim Biophys Acta, 2012 Feb. 2. Chhunchha B, et al. Aberrant sumoylation signaling evoked by reactive oxygen species impairs protective function of Prdx6 by destabilization and repression of its transcription. FEBS J, 2014 Aug. 3. Guo HW, et al. Expression of peroxiredoxin 6 in gastric cancer and its clinical significance. Zhonghua Yi Xue Za Zhi, 2012 Sep 11.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
25035 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Peroxiredoxin-6
Subcellular Location
Cytoplasm . Lysosome . Cytoplasmic vesicle . Also found in lung secretory organelles. .
Sequence Similarities
Belongs to the AhpC/TSA family. Rehydrin subfamily.
Protein Name
Peroxiredoxin-6
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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