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Anti-Otx2 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

OTX2 is also known as CPHD6 or MCOPS5. This gene encodes a member of the bicoid subfamily of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and plays a role in brain, craniofacial, and sensory organ development. The encoded protein also influences the proliferation and differentiation of dopaminergic neuronal progenitor cells during mitosis. Mutations in this gene cause syndromic microphthalmia 5 (MCOPS5) and combined pituitary hormone deficiency 6 (CPHD6) . This gene is also suspected of having an oncogenic role in medulloblastoma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Pseudogenes of this gene are known to exist on chromosomes two and nine.

Synonyms

Homeobox protein OTX2; Orthodenticle homolog 2; OTX2

Gene Name

OTX2

Gene ID

5015

UniProt

P32243

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human Otx2, identical to the related mouse sequence.

Clonality

Polyclonal

Tissue Specificity

Expressed in brain.

Applications

Flow Cytometry

Field of Research

2339, Developmental Biology, Embryogenesis, Epigenetics and Nuclear Signaling, Lineage Markers, Lineage Specification, Nervous System Development, Neurogenesis, Neurology Process, Neuroscience, Organogenesis, Sensory System, Stem Cells, Transcription, Visual System

Purification

Immunogen affinity purified.

Form

Liquid

Function

Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS) : 5'-TCTAATCCC-3'.

References & Citations

1. Bunt J, et al. OTX2 sustains a bivalent-like state of OTX2-bound promoters in medulloblastoma by maintaining their H3K27me3 levels. Acta Neuropathol, 2013 Mar. 2. Gat-Yablonski G. Brain development is a multi-level regulated process--the case of the OTX2 gene. Pediatr Endocrinol Rev, 2011 Sep. 3. Liu Z, et al. Specific expression pattern of a novel Otx2 splicing variant during neural differentiation. Gene, 2013 Jul 1.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

31636 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Homeobox protein OTX2

Subcellular Location

Nucleus .

Sequence Similarities

Belongs to the paired homeobox family. Bicoid subfamily.

Protein Name

Homeobox protein OTX2

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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