Anti-Calpain 1/CAPN1 Antibody Picoband® Fluoro488 Conjugated
Selected Variant
PB9330-Fluoro488
Size: 100 µg/Vial
Product Specifications
Background
CAPN1 is also known as CANP or muCL. The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene.
Synonyms
Calpain-1 catalytic subunit;3.4.22.52; Calcium-activated neutral proteinase 1; CANP 1; Calpain mu-type; Calpain-1 large subunit; Cell proliferation-inducing gene 30 protein; Micromolar-calpain; muCANP; CAPN1; CANPL1; PIG30
Gene Name
CAPN1
Gene ID
823
UniProt
P07384
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
E.coli-derived human Calpain 1 recombinant protein (Position: Q396-A555) . Human Calpain 1 shares 86% amino acid (aa) sequence identity with both mouse and rat Calpain 1.
Clonality
Polyclonal
Tissue Specificity
Ubiquitous.
Applications
Flow Cytometry
Field of Research
Calcium Signaling, Cell Biology, Proteolysis/Ubiquitin, Proteolytic Enzymes, Signal Transduction, Signaling Pathway
Purification
Immunogen affinity purified.
Form
Liquid
Function
Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
References & Citations
1. Smith IJ, et al. Calpain activity is increased in skeletal muscle from gastric cancer patients with no or minimal weight loss. Muscle Nerve, 2011 Mar. 2. Wang JC, et al. Proteolysis by endogenous calpain I leads to the activation of calcineurin in human heart. Clin Lab, 2012.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
81890 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Calpain-1 catalytic subunit
Subcellular Location
Cytoplasm . Cell membrane . Translocates to the plasma membrane upon Ca (2+) binding. In granular keratinocytes and in lower corneocytes, colocalizes with FLG and FLG2 (PubMed:21531719) . .
Sequence Similarities
Belongs to the peptidase C2 family.
Protein Name
Calpain-1 catalytic subunit
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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