Anti-Mucin 5AC/MUC5AC Antibody Fluoro647 Conjugated
Product Specifications
Background
Mucin-5AC is a protein that in humans is encoded by the MUC5AC gene. It is mapped to 11p15.5. MUC5AC is highly expressed in adult trachea and stomach. This gene has been linked to mucus hypersecretion in the pulmonary tracts and associated to chronic obstructive pulmonary disease (COPD) . It has been showed that activation of the NF-kappa-B signaling pathway by inflammatory cytokine TNF-alpha upregulated MUC5AC mRNA expression nearly 6-fold. MUC5AC is also a and critical mediator of resistance during intestinal nematode infection.
Synonyms
Mucin-5AC ; MUC-5AC ; Gastric mucin ; Lewis B blood group antigen ; LeB ; Major airway glycoprotein ; Mucin-5 subtype AC, tracheobronchial; Tracheobronchial mucin ; TBM ; MUC5AC ; MUC5
Gene Name
MUC5AC
Gene ID
4586
UniProt
P98088
Host
Rabbit
Reactivity
Human, Rat
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
E.coli-derived human Mucin 5AC recombinant protein (Position: D4848-H5030) .
Clonality
Polyclonal
Tissue Specificity
Highly expressed in surface mucosal cells of respiratory tract and stomach epithelia. Overexpressed in a number of carcinomas. Also expressed in Barrett's esophagus epithelium and in the proximal duodenum. .
Applications
Flow Cytometry
Field of Research
Cancer, Cytoskeleton/ECM, ECM Proteins, Extracellular Matrix, Invasion/Microenvironment, Signal Transduction, Tumor Antigens, Tumor Biomarkers, Tumor Immunology, Tumor-Associated Antigens
Purification
Immunogen affinity purified.
Form
Liquid
Function
Gel-forming glycoprotein of gastric and respiratoy tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microrganisms and particles that are subsequently removed by the mucocilary system.
References & Citations
1. Hasnain, S. Z., Evans, C. M., Roy, M., Gallagher, A. L., Kindrachuk, K. N., Barron, L., Dickey, B. F., Wilson, M. S., Wynn, T. A., Grencis, R. K., Thornton, D. J. Muc5ac: a critical component mediating the rejection of enteric nematodes. J. Exp. Med. 208: 893-900, 2011. 2. Moehle, C., Ackermann, N., Langmann, T., Aslanidis, C., Kel, A., Kel-Margoulis, O., Schmitz-Madry, A., Zahn, A., Stremmel, W., Schmitz, G. Aberrant intestinal expression and allelic variants of mucin genes associated with inflammatory bowel disease. J. Molec. Med. 84: 1055-1066, 2006. 3. Wang G, Xu Z, Wang R, Al-Hijji M, Salit J, Strulovici-Barel Y, Tilley A, Mezey J, Crystal R (June 2012) . Genes associated with MUC5AC expression in small airway epithelium of human smokers and nonsmokers. BMC Med Genomics5 (1) : 21.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
585570 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Mucin-5AC
Subcellular Location
Secreted .
Sequence Similarities
Contains 1 CTCK (C-terminal cystine knot-like) domain.
Protein Name
Mucin-5AC
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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