Anti-Mesothelin/MSLN Antibody Picoband® Fluoro594 Conjugated
Product Specifications
Background
Mesothelin, also known as MSLN or MPF is a protein that in humans is encoded by the MSLN gene. This gene is mapped to 16p13.3. This gene encodes a precursor protein that is cleaved into two products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiation factor functions as a cytokine that can stimulate colony formation in bone marrow megakaryocytes. Mesothelian is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas.
Synonyms
Mesothelin; CAK1 antigen; Pre-pro-megakaryocyte-potentiating factor; Megakaryocyte-potentiating factor; MPF; Mesothelin, cleaved form; MSLN; MPF
Gene Name
MSLN
Gene ID
10232
UniProt
Q13421
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
E.coli-derived human Mesothelin recombinant protein (Position: K306-L576) . Human Mesothelin shares 57% and 56% amino acid (aa) sequence identity with mouse and rat Mesothelin, respectively.
Clonality
Polyclonal
Tissue Specificity
Expressed in lung. Expressed at low levels in heart, placenta and kidney. Expressed in mesothelial cells. Highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level) . .
Applications
Flow Cytometry
Field of Research
Tumor Biomarkers, Tumor Immunology, Tumor-Associated Antigens
Purification
Immunogen affinity purified.
Form
Liquid
Function
Membrane-anchored forms may play a role in cellular adhesion.
References & Citations
1. Bera, T. K., Pastan, I. Mesothelin is not required for normal mouse development or reproduction. Molec. Cell. Biol. 20: 2902-2906, 2000. 2. Scholler, N., Fu, N., Yang, Y., Ye, Z., Goodman, G. E., Hellstrom, K. E., Hellstrom, I. Soluble member (s) of the mesothelin/megakaryocyte potentiating factor family are detectable in sera from patients with ovarian carcinoma. Proc. Nat. Acad. Sci. 96: 11531-11536, 1999.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
68986 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Mesothelin
Subcellular Location
Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus.
Protein Name
Mesothelin
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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